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Artesunate inhibits adipogeneis in 3T3-L1 preadipocytes by reducing the expression and/or phosphorylation levels of C/EBP-α, PPAR-γ, FAS, perilipin A, and STAT-3

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Author(s)
Byeong-Churl Jang
Keimyung Author(s)
Jang, Byeong Churl
Department
Dept. of Molecular Medicine (분자의학)
Journal Title
Biochemical and Biophysical Research Communications
Issued Date
2016
Volume
474
Issue
1
Keyword
ArtesunateAdipogenesisPPAR-gC/EBP-aSTAT-3FAS
Abstract
Differentiation of preadipocyte, also called adipogenesis, leads to the phenotype of mature adipocyte.
However, excessive adipogenesis is closely linked to the development of obesity. Artesunate, one of
artemisinin-type sesquiterpene lactones from Artemisia annua L., is known for anti-malarial and anticancerous
activities. In this study, we investigated the effect of artesunate on adipogenesis in 3T3-L1
preadipocytes. Artesunate strongly inhibited lipid accumulation and triglyceride (TG) synthesis during
the differentiation of 3T3-L1 preadipocytes into adipocytes at 5 mM concentration. Artesunate at 5 mM
also reduced not only the expressions of CCAAT/enhancer-binding protein-a (C/EBP-a), peroxisome
proliferator-activated receptor-g (PPAR-g), fatty acid synthase (FAS), and perilipin A but also the phosphorylation
levels of signal transducer and activator of transcription-3 (STAT-3) during adipocyte differentiation.
Moreover, artesunate at 5 mM reduced leptin, but not adiponectin, mRNA expression during
adipocyte differentiation. Taken together, these findings demonstrate that artesunate inhibits adipogenesis
in 3T3-L1 preadipoytes through the reduced expression and/or phosphorylation levels of C/EBPa,
PPAR-g, FAS, perilipin A, and STAT-3.
Keimyung Author(s)(Kor)
장병철
Publisher
School of Medicine
Citation
Byeong-Churl Jang. (2016). Artesunate inhibits adipogeneis in 3T3-L1 preadipocytes by reducing the expression and/or phosphorylation levels of C/EBP-α, PPAR-γ, FAS, perilipin A, and STAT-3. Biochemical and Biophysical Research Communications, 474(1), 220–225. doi: 10.1016/j.bbrc.2016.04.109
Type
Article
ISSN
0006-291X
Source
https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(16)30614-3
DOI
10.1016/j.bbrc.2016.04.109
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33135
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Molecular Medicine (분자의학)
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