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Being Overweight or Obese Increases the Risk of Progression in Triple-Negative Breast Cancer after Surgical Resection

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Author(s)
Yunseon ChoiSung Kwang ParkKi Jung AhnHeunglae ChoTae Hyun KimHye Kyoung YoonYun-Han Lee
Keimyung Author(s)
Lee, Yun Han
Department
Dept. of Molecular Medicine (분자의학)
Journal Title
Journal of Korean Medical Science
Issued Date
2016
Volume
31
Issue
6
Keyword
Triple-Negative Breast CancerOverweightObesityBody Mass IndexPrognosis
Abstract
This study aimed to evaluate the association between body mass index (BMI) and
progression in triple-negative breast cancer (TNBC). We retrospectively reviewed the
medical records of 50 patients with TNBC who underwent breast-conserving surgery or
mastectomy between 2007 and 2014. All patients were classified according to BMI (median
23.5 kg/m2
, range 17.2-31.6 kg/m2
): 31 patients (62%) were classified as being overweight
or obese (BMI ≥ 23 kg/m2
) and 19 patients (38%) were classified as having a normal body
weight (BMI < 23 kg/m2
). The median follow-up for patients was 31.1 months (range,
6.7-101.9 months). Progression occurred in 7 patients (14%), including 5 ipsilateral breast
tumor recurrences, 2 regional lymph node metastases, and 5 distant metastases.
Progression was significantly correlated with overweight or obese patients (P = 0.035),
while none of the normal weight patients showed progression. The 3-year disease-free
survival (DFS) and overall survival (OS) rates were 85.0% and 87.7%, respectively. DFS was
significantly reduced in overweight or obese patients compared to that in normal weight
patients (P = 0.035). However, OS was not significantly compromised by being overweight
or obese (P = 0.134). In conclusion, being overweight or obese negatively affects DFS in
TNBC patients.
Keimyung Author(s)(Kor)
이윤한
Publisher
School of Medicine
Citation
Yunseon Choi et al. (2016). Being Overweight or Obese Increases the Risk of Progression in Triple-Negative Breast Cancer after Surgical Resection. Journal of Korean Medical Science, 31(6), 886–891. doi: 10.3346/jkms.2016.31.6.886
Type
Article
ISSN
1011-8934
DOI
10.3346/jkms.2016.31.6.886
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33140
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Molecular Medicine (분자의학)
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