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Biologic subtype is a more important prognostic factor than nodal involvement in patients with stages I and II breast carcinoma

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Author(s)
Hyosun KimJihyoung ChoSun Young KwonSun Hee Kang
Keimyung Author(s)
Cho, Ji HyoungKang, Sun HeeKwon, Sun Young
Department
Dept. of Surgery (외과학)
Dept. of Pathology (병리학)
Journal Title
Annals of Surgical Treatment and Research
Issued Date
2016
Volume
90
Issue
1
Keyword
Breast neoplasmsLymphatic metastasisPrognosisTriple negative breast neoplasms
Abstract
Purpose: Nodal infiltration has been one of the most important prognostic factors in breast cancer. In recent decades,
risk stratification has greatly changed, and is applied in accordance with hormone receptor and human epidermal growth
factor receptor 2 (HER2) status. We compared the prognostic power of tumor subtype to nodal involvement in early breast
cancer.
Methods: We reviewed the medical records of 505 patients who had curative surgery for stage I or II breast cancer. We
analyzed clinicopathologic factors according to tumor subtype and nodal involvement. Tumors were classified into 4
subtypes according to immunohistochemical status of estrogen receptor, progesterone receptor, HER2, and Ki67 labeling
index. Disease-free survival (DFS) and overall survival were analyzed.
Results: There were 363 node-negative patients (71.9%) and 142 node-positive patients (28.1%). Luminal A, Luminal B,
HER2, and triple-negative breast cancer subtypes were composed of 207 (41.0%), 147 (29.1%), 42 (8.3%), and 109 patients
(21.6%), respectively. The median follow-up period was 89.5 months. Node negative-luminal A subtype showed the best
prognosis with regard to 5-year DFS, and the pN1-triple negative subtype was associated with the shortest DFS (95.1% vs.
67.8%; hazard ratio, 9.554; P < 0.001). However, the node negative-triple negative subtype was associated with a worse
5-year DFS than the pN1-luminal A subtype ([86.4%; hazard ratio, 2.647; P = 0.048] vs. [93.2%; hazard ratio, 2.061; P = 0.194]).
Conclusion: Node negative-triple negative breast cancer was associated with a poorer prognosis than pN1-luminal A
subtype. Tumor subtype has greater prognostic power compared to nodal status in early breast cancer.
Keimyung Author(s)(Kor)
조지형
강선희
권선영
Publisher
School of Medicine
Citation
Hyosun Kim et al. (2016). Biologic subtype is a more important prognostic factor than nodal involvement in patients with stages I and II breast carcinoma. Annals of Surgical Treatment and Research, 90(1), 1–9. doi: 10.4174/astr.2016.90.1.1
Type
Article
ISSN
2288-6575
DOI
10.4174/astr.2016.90.1.1
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33143
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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