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Changes in one-carbone metabolism after duodenal-jejunal bypass surgery

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Author(s)
Jeeyoun Jung, Tae Kyung Ha, Jueun Lee, Yunmee Lho, Miso Nam, Doohae Lee, Carel W. le Roux, Do Hyun Ryu, Eunyoung Ha, Geum-Sook Hwang
Keimyung Author(s)
Ha, Eun Young
Department
Dept. of Biochemistry (생화학)
Journal Title
American Journal of Physiology -Endocrinology and Metabolism
Issued Date
2016
Volume
310
Issue
8
Keyword
Gastric bypass surgeryMetabolomicsProteomicsMetabolism
Abstract
Bariatric surgery alleviates obesity and ameliorates glucose tolerance. Using metabolomic and proteomic profiles, we evaluated metabolic changes in serum and liver tissue after duodenal-jejunal bypass (DJB) surgery in rats fed a normal chow diet. We found that the levels of vitamin B12 in the sera of DJB rates were decreased. In the liver of DJB rats, betaine-homocysteine S-methyltransferase levels were decreased, whereas serine, cystathionine, cysteine, glutathione, cystathionine β-synthase, glutathione S-transferase, and aldehyde dehydrogenase levels were increased. These results suggested that DJB surgery enhanced trans-sulfuration and its consecutive reactions such as detoxification and the scavenging activities of reactive oxygen species. In addition, DJB rats showed higher levels of purine metabolites such as ATP, ADP, AMP, and inosine monophosphate. Decreased guanine deaminase, as well as lower levels of hypoxanthine, indicated that DJB surgery limited the purine degradation process. In particular, the AMP/ATP ratio and phosphorylation of AMP-activated protein kinase increased after DJB surgery, which led to enhanced energy production and increased catabolic pathway activity, such as fatty acid oxidation and glucose transport. This study shows that bariatric surgery altered trans-sulfuration and purine metabolism in the liver. Characterization of these mechanisms increases our understanding of the benefits of bariatric surgery.
Keimyung Author(s)(Kor)
하은영
Publisher
School of Medicine
Citation
Jeeyoun Jung, Tae Kyung Ha, Jueun Lee, Yunmee Lho, Miso Nam, Doohae Lee, Carel W. le Roux, Do Hyun Ryu, Eunyoung Ha, Geum-Sook Hwang. (2016). Changes in one-carbone metabolism after duodenal-jejunal bypass surgery. American Journal of Physiology -Endocrinology and Metabolism, 310(8), E624–E632. doi: 10.1152/ajpendo.00260.2015
Type
Article
ISSN
0193-1849
DOI
10.1152/ajpendo.00260.2015
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33145
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
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