Clinical Features and Survival of Patients With Follicular Lymphoma in Korea
- Author(s)
- Su-Hee Cho; Cheolwon Suh; Young Rok Do; Je-Jung Lee; Hwan-Jung Yun; Sung Young Oh; Ho Sup Lee; Seok-Goo Cho; In Sung Cho; Won-Sik Lee; Young-Woong Won; Hyo Jung Kim; Hong Ghi Lee; Soon Il Lee; Sung-Nam Lim; Byeong Seok Sohn; Heui June Ahn; Myung Hee Chang; Kyung A. Kwon; Won Seog Kim
- Keimyung Author(s)
- Do, Young Rok
- Department
- Dept. of Internal Medicine (내과학)
- Journal Title
- Clinical Lymphoma, Myeloma and Leukemia
- Issued Date
- 2016
- Volume
- 16
- Issue
- 4
- Keyword
- Ann-Arbor Stage; Asia; Bcl-2; Grade; Western
- Abstract
- We performed a retrospective analysis of 343 patients diagnosed with follicular lymphoma in Korea who
showed some different tendencies compared with patients in Western countries. The grade was high and the
stage relatively low. Bcl-2 expression was also low; however, except for these factors, most of the characteristics
were similar.
Background: The incidence of follicular lymphoma (FL) varies according to geographic location. It is the second most
common non-Hodgkin lymphomainWestern countries but has a very lowincidence inAsia. Thus, no representative data are
available for FL. Therefore, we gathered our own data to build a foundation for FL research. Patients and Methods: We
collected a total of 343 patient records. The median age was 53 years, and the ratio of male to female patients was 1.4:1.
Most patients received chemotherapy with or without rituximab. Results: The incidence of grade 1 and 2 FL was 64.9%
(n ¼ 205) and of stage III and IV was 51.2% (n ¼ 171). The grade tended to be higher and the stage to be lower compared
with Western data. In the chemotherapy group, the complete response rate was 76.0%, and the partial response rate was
17.1%. The median follow-up duration was 38.1 months. The estimated 5- and 10-year progression-free survival and
overall survival rates were 68.3% and 84.9% and 63.0% and 71.3%, respectively. Conclusion: We could not find
definitive differences between our Korean data and the Western data, although we found some trends in the baseline
characteristics. Therefore, we hope to develop an understanding of FL and perform more qualitative studies in the future.
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