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Clinical Significance of the Number of Depressive Symptoms in Major Depressive Disorder: Results from the CRESCEND Study

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Author(s)
Seon-Cheol ParkJeongkyu SakongBon Hoon KooJae-Min KimTae-Youn JunMin-Soo LeeJung-Bum KimHyeon-Woo YimYong Chon Park
Keimyung Author(s)
Kim, Jung Bum
Department
Dept. of Psychiatry (정신건강의학)
Journal Title
Journal of Korean Medical Science
Issued Date
2016
Volume
31
Issue
4
Keyword
NumberMajor Depressive Disorder (MDD)Depressive SymptomsAnxiety SymptomsSuicidal Ideation
Abstract
Our study aimed to establish the relationship between the number of depressive symptoms
and the clinical characteristics of major depressive disorder (MDD). This would enable us to
predict the clinical significance of the number of depressive symptoms in MDD patients.
Using data from the Clinical Research Center for Depression (CRESCEND) study in Korea,
853 patients with DSM-IV MDD were recruited. The baseline and clinical characteristics of
groups with different numbers of depressive symptoms were compared using the χ2 test for
discrete variables and covariance (ANCOVA) for continuous variables. In addition, the
scores of these groups on the measurement tools were compared by ANCOVA after
adjusting the potential effects of confounding variables. After adjusting the effects of
monthly income and history of depression, a larger number of depressive symptoms
indicated higher overall severity of depression (F [4, 756] = 21.458, P < 0.001) and higher
levels of depressive symptoms (F [4, 767] = 19.145, P < 0.001), anxiety symptoms (F [4,
765] = 12.890, P < 0.001), and suicidal ideation (F [4, 653] = 6.970, P < 0.001). It also
indicated lower levels of social function (F [4, 760] = 13.343, P < 0.001), and quality of
life (F [4, 656] = 11.975, P < 0.001). However, there were no significant differences in
alcohol consumption (F [4, 656] = 11.975, P < 0.001). The number of depressive
symptoms can be used as an index of greater illness burden in clinical psychiatry.
Keywords: Number; Major Depressive Disorder (MDD); Depressive Symptoms; Anxiety
Symptoms; Suicidal Ideation
Keimyung Author(s)(Kor)
김정범
Publisher
School of Medicine
Citation
Seon-Cheol Park et al. (2016). Clinical Significance of the Number of Depressive Symptoms in Major Depressive Disorder: Results from the CRESCEND Study. Journal of Korean Medical Science, 31(4), 617–622. doi: 10.3346/jkms.2016.31.4.617
Type
Article
ISSN
1011-8934
DOI
10.3346/jkms.2016.31.4.617
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33157
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Psychiatry (정신건강의학)
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