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Decreased Morbidity of Laparoscopic Distal Gastrectomy Compared With Open Distal Gastrectomy for Stage I Gastric Cancer: Short-term Outcomes From a Multicenter Randomized Controlled Trial (KLASS-01)

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Author(s)
Wook KimHyung-Ho KimSang-Uk HanMin-Chan KimWoo Jin HyungSeung Wan RyuGyu Seok ChoChan Young KimHan-Kwang YangDo Joong ParkKyo Young SongSang Il LeeSeung Yub RyuJoo-Ho LeeHyuk-Joon Lee
Keimyung Author(s)
Ryu, Seung Wan
Department
Dept. of Surgery (외과학)
Journal Title
Annals of Surgery
Issued Date
2016
Volume
263
Issue
1
Keyword
ComplicationLaparoscopyMorbidityMortalityStomach neoplasm
Abstract
Objective: To determine the safety of laparoscopy-assisted distal gastrectomy
(LADG) compared with open distal gastrectomy (ODG) in patients with
clinical stage I gastric cancer in Korea.
Background: There is still a lack of large-scale, multicenter randomized
trials regarding the safety of LADG.
Methods: A large-scale, phase 3, multicenter, prospective randomized controlled
trial was conducted. The primary end point was 5-year overall survival.
Morbidity within 30 postoperative days and surgical mortality were compared
to evaluate the safety of LADG as a secondary end point
Results: A total of 1416 patients were randomly assigned to the LADG group
(n¼705) or the ODG group (n¼711) between February 1, 2006, and August
31, 2010, and 1384 patients were analyzed for modified intention-to-treat
analysis (ITT) and 1256 were eligible for per protocol (PP) analysis (644 and
612, respectively). In the PP analysis, 6 patients (0.9%) needed open conversion
in the LADG group. The overall complication rate was significantly
lower in the LADG group (LADG vs ODG; 13.0% vs 19.9%, P¼0.001). In
detail, the wound complication rate of the LADG group was significantly
Keimyung Author(s)(Kor)
류승완
Publisher
School of Medicine
Citation
Wook Kim et al. (2016). Decreased Morbidity of Laparoscopic Distal Gastrectomy Compared With Open Distal Gastrectomy for Stage I Gastric Cancer: Short-term Outcomes From a Multicenter Randomized Controlled Trial (KLASS-01). Annals of Surgery, 263(1), 28–35. doi: 10.1097/SLA.0000000000001346
Type
Article
ISSN
0003-4932
Source
https://insights.ovid.com/crossref?an=00000658-201601000-00006
DOI
10.1097/SLA.0000000000001346
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33175
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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