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Different Loss of Dopamine Transporter according to Metabolic Subtypes of Multiple System Atrophy

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Author(s)
Hae Won KimJae Seung KimMinyoung OhJungsu S. OhSang Joo LeeSeung Jun OhSun Ju ChungChong Sik Lee
Keimyung Author(s)
Kim, Hae Won
Department
Dept. of Nuclear Medicine (핵의학)
Journal Title
European Journal of Nuclear Medicine and Molecular Imaging
Issued Date
2016
Volume
43
Issue
3
Keyword
Multiple system atrophyDopamine transporter[18F]FP-CIT
Abstract
Purpose The aimof this study was to evaluate whether striatal
dopamine transporter (DAT) loss as measured by 18F-fluorinated-
N-3-fluoropropyl-2-b-carboxymethoxy-3-b-(4-
iodophenyl) nortropane ([18F]FP-CIT) PET differs according
to the metabolic subtype of multiple system atrophy (MSA) as
assessed by [18F]FDG PET.
Methods This retrospective study included 50 patients with
clinically diagnosed MSA who underwent [18F]FP-CIT and
[18F]FDG brain PET scans. The PET images were analysed
using 12 striatal subregional volume-of-interest templates (bilateral
ventral striatum, anterior caudate, posterior caudate,
anterior putamen, posterior putamen, and ventral putamen).
The patients were classified into three metabolic subtypes according
to the [18F]FDG PET findings: MSA-Pm (striatal
hypometabolism only), MSA-mixedm (both striatal and cerebellar
hypometabolism), and MSA-Cm (cerebellar
hypometabolism only). The subregional glucose metabolic
ratio (MRgluc), subregional DAT binding ratio (BRDAT), and
intersubregional ratio (ISRDAT; defined as the BRDAT ratio of
one striatal subregion to that of another striatal subregion)
were compared according to metabolic subtype.
Results Of the 50 patients, 13 presented with MSA-Pm, 16
presented with MSA-mixedm, and 21 presented with MSACm.
The BRDAT of all striatal subregions in the MSA-Pm and
MSA-mixedm groups were significantly lower than those in
the MSA-Cm group. The posterior putamen/anterior putamen
ISRDAT and anterior putamen/ventral striatum ISRDAT in the
MSA-Pm and MSA-mixedm groups were significantly lower
than those in the MSA-Cm group.
Conclusion Patients with MSA-Pm and MSA-mixedm
showed more severe DAT loss in the striatum than patients
with MSA-Cm. Patients with MSA-Cm had more diffuse DAT
loss than patients with MSA-Pm and MSA-mixedm.
Keimyung Author(s)(Kor)
김해원
Publisher
School of Medicine
Citation
Hae Won Kim et al. (2016). Different Loss of Dopamine Transporter according to Metabolic Subtypes of Multiple System Atrophy. European Journal of Nuclear Medicine and Molecular Imaging, 43(3), 517–525. doi: 10.1007/s00259-015-3191-6
Type
Article
ISSN
1619-7070
Source
http://lps3.link.springer.com.proxy.dsmc.or.kr/article/10.1007%2Fs00259-015-3191-6
DOI
10.1007/s00259-015-3191-6
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33181
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학)
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