계명대학교 의학도서관 Repository

Effect of Recombinant Human Bone Morphogenetic Protein-2 and Adipose Tissue-Derived Stem Cell on New Bone Formation in High-Speed Distraction Osteogenesis.

Metadata Downloads
Author(s)
Suk Wha KimSung Joo LeeByung Jun KimYoung Il KimChul-Ho SohnYoon Kyung JeonLianji XuSang Hyon KimSun Young KwonTae Hyun Choi
Keimyung Author(s)
Kwon, Sun YoungKim, Sang Hyon
Department
Dept. of Pathology (병리학)
Dept. of Internal Medicine (내과학)
Journal Title
Cleft Palate - Craniofacial Journal.
Issued Date
2016
Volume
53
Issue
1
Keyword
Adipose tissue-derived stem cellAdult rabbitBone morphogenetic protein-2Distraction osteogenesis of cranial bone
Abstract
Purpose: The effects of recombinant human bone morphogenetic protein-2 (rhBMP-2) and
osteogenically differentiated adipose tissue-derived stem cells (ADSC) on new bone formation in
high-speed distraction osteogenesis of adult rabbit cranium were investigated.
Materials and Methods: A total of 41 adult rabbits were used in the study. Distraction began
after a 5-day latency period at a rate of 1.5 mm twice a day until 10-mm length gain was obtained
both in the control group, where a bone defect was induced, and in the experimental group, in
which ADSC (group A), rhBMP-2 (group B), or both (group C) were injected in the distraction gap
after distraction. At 4, 8, and 12 weeks after distraction, computed tomography analysis was
done to determine the bone defect dimension and bone mineral density (BMD), while histologic
examination was also done to calculate bone formation ratio.
Results: Bone defect dimension significantly decreased in groups B and C, compared with
the control group, at 4 and 12 weeks after distraction. BMD was significantly increased in groups
B and C at 4 weeks. On histologic examination, bone formation ratio was significantly increased
in group C only at 12 weeks.
Conclusion: This study suggests that the use of rhBMP-2 in combination with or without
ADSC is helpful to promote bone regeneration in high-speed distraction osteogenesi s of adult
rabbit cranium.
Keimyung Author(s)(Kor)
권선영
김상현
Publisher
School of Medicine
Citation
Suk Wha Kim et al. (2016). Effect of Recombinant Human Bone Morphogenetic Protein-2 and Adipose Tissue-Derived Stem Cell on New Bone Formation in High-Speed Distraction Osteogenesis. Cleft Palate - Craniofacial Journal., 53(1), 84–92. doi: 10.1597/12-290
Type
Article
ISSN
1055-6656
Source
http://journals.sagepub.com/doi/abs/10.1597/12-290?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
DOI
10.1597/12-290
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33186
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.