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Effective bolus dose of sufentanil to attenuate cardiovascular responses in laryngoscopic double-lumen endobronchial intubation

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Author(s)
Byung-Hee ChoiYong-Cheol Lee
Keimyung Author(s)
Lee, Yong Cheol
Department
Dept. of Anesthesiology & Pain Medicine (마취통증의학)
Journal Title
Anesthesiology and Pain Medicine
Issued Date
2016
Volume
6
Issue
2
Keyword
CardiovascularHemodynamicIntubationLaryngoscopyOne-Lung VentilationSufentanil
Abstract
Background: Sufentanil is a potent opioid analgesic frequently used in clinical anesthesia. Double-lumen endobronchial intubation
induces profound cardiovascular responses in comparison with ordinary endotracheal intubation because of the larger tube
diameter and direct irritation of the carina.
Objectives: The purpose of this study was to determine the effective bolus dose of sufentanil to attenuate hemodynamic changes
in response to laryngoscopic double-lumen endobronchial intubation.
Patients and Methods: We randomly assigned 72 patients aged 18 - 65 years and with an American Society of Anesthesiologists
physical status of 1 or 2 to one of four sufentanil dose groups: NS, S0.1, S0.2, or S0.3. The respective doses for the groups were as
follows: normal saline, 0.1 mcg/kg of sufentanil, 0.2 mcg/kg of sufentanil, and0.3 mcg/kg of sufentanil. Blood pressure andheart rate
were recorded during the pre-anesthesia period at baseline, pre-intubation, immediate post-intubation, and every minute during
5 minutes after intubation.
Results: Baselinemeanarterial pressures in the NS, S0.1, S0.2, and S0.3 groups were 89.8 12.1, 89.2 10.9, 88.8 13.6, and 90.7 11.1,
respectively. At immediate post-intubation, the mean arterial pressures in the NS, S0.1, S0.2, and S0.3 groups were 129.7 14.7, 120.7
14.2, 120.8 17.2, and 96.7 10.4, respectively. At immediate post-intubation, the mean arterial pressure in the NS, S0.1, and S0.2
groups significantly increased from baseline (P < 0.001), but the S0.3 group showed no difference. In the time point comparison at
immediate post- intubation, the S0.3 group had a significantly lower mean arterial pressure than did the NS, S0.1, and S0.2 groups
(P < 0.001).
Conclusions: We found that 0.3 mcg/kg of sufentanil attenuates cardiovascular responses to double-lumen endobronchial intubation
without adverse effects.
Keimyung Author(s)(Kor)
이용철
Publisher
School of Medicine
Citation
Byung-Hee Choi and Yong-Cheol Lee. (2016). Effective bolus dose of sufentanil to attenuate cardiovascular responses in laryngoscopic double-lumen endobronchial intubation. Anesthesiology and Pain Medicine, 6(2), e33640–e33640. doi: 10.5812/aapm.33640
Type
Article
ISSN
2228-7523
DOI
10.5812/aapm.33640
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33188
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anesthesiology & Pain Medicine (마취통증의학)
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