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Failure of fixation suppression of spontaneous nystagmus in cerebellar infarction: frequency, pattern and a possible structure

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Author(s)
Hyun-Ah KimHyon-Ah YiHyung Lee
Keimyung Author(s)
Kim, Hyun AhYi, Hyon AhLee, Hyung
Department
Dept. of Neurology (신경과학)
Brain Research Institute (뇌연구소)
Journal Title
Cerebellum
Issued Date
2016
Volume
15
Issue
2
Keyword
CerebellumSpontaneous nystagmusOcular fixationCerebellar infarction
Abstract
To investigate the frequency and pattern of failure
of the fixation suppression (FFS) of spontaneous nystagmus
(SN) in unilateral cerebellar infarction, and to identify the
structure responsible for FFS, 29 patients with acute, mainly
unilateral, isolated cerebellar infarction who had SN with a
predominantly horizontal component were enrolled in this
study. The ocular fixation index (OFI) was defined as the
mean slow phase velocity (SPV) of the horizontal component
of SN with fixation divided by the mean SPVof the horizontal
component of SN without fixation. The OFI from age- and
sex-matched patients with vestibular neuritis was calculated
and used as the control data. The FFS of SN was only found in
less than half (41 %, 12/29) of the patients. Approximately
65 % (n=7) of the patients with isolated anterior inferior cerebellar
artery territory cerebellar infarction showed FFS,
whereas only a quarter (n=3) of the patients with isolated
posterior inferior cerebellar artery (PICA) territory cerebellar
infarction showed FFS. The proportion of gaze-evoked nystagmus
(6/12 [50 %] vs. 2/17 [12 %], p=0.04) and deficient
gain of ipsilesional pursuit (10/12 [83 %] vs. 6/17 [35 %], p=
0.05) was more frequent in the FFS group than in the group
without FFS. Lesion subtraction analysis in isolated PICA
territory cerebellar infarction revealed that the nodulus was
commonly damaged in patients with FFS, compared to that
of patients without FFS. Our study shows that FFS of SN due
to acute cerebellar infarction is less common than previously
thought and the nodulus may be an important structure for the
suppression of SN in humans.
Keimyung Author(s)(Kor)
김현아
이현아
이형
Publisher
School of Medicine
Citation
Hyun-Ah Kim et al. (2016). Failure of fixation suppression of spontaneous nystagmus in cerebellar infarction: frequency, pattern and a possible structure. Cerebellum, 15(2), 182–189. doi: 10.1007/s12311-015-0688-2
Type
Article
ISSN
1473-4222
Source
https://link.springer.com/article/10.1007%2Fs12311-015-0688-2
DOI
10.1007/s12311-015-0688-2
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33202
Appears in Collections:
3. Research Institutues (연구소) > Brain Research Institute (뇌연구소)
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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