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Health-Related Quality of Life and Sociodemographic Characteristics as Prognostic Indicators of Long-term Survival in Disease-Free Cervical Cancer Survivors

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Author(s)
Mi-Kyung KimJin Ah SimYoung Ho YunDuk-Soo BaeJoo Hyun NamChong Taik ParkChi-Heum ChoJong-Min LeeSang Yoon Park
Keimyung Author(s)
Cho, Chi Heum
Department
Dept. of Obstetrics & Gynecology (산부인과학)
Journal Title
International Journal of Gynecological Cancer
Issued Date
2016
Volume
26
Issue
4
Keyword
Cervical cancerCancer survivorshipHealth-related quality of lifePrognostic factors
Abstract
Objectives: Health-related quality-of-life (HRQOL) issues of cancer patients are considered
an important clinical outcome. We aimed to investigate the prognostic value of
HRQOL on long-term survival outcomes in disease-free cervical cancer survivors (CCSs).
Methods: The study sample consisted of 860 disease-free CCSs from 6 Korean cancer
hospitals recruited for HRQOL survey during 2005 (median time from diagnosis, 5.9 years).
Health-related quality-of-life measures included the European Organization for Research
and Treatment of Cancer QLQ-C30 and its Cervical Cancer Module (CX24). Survival data
were retrieved from the Korean Statistical Office after 6 years from the survey. Health-related
quality-of-life domains along with sociodemographic and clinicopathologic variables were
analyzed as prognostic factors for survival from the date of survey.
Results: During the median follow-up period of 6.3 years after the survey, 30 (3.5%)
patients died from all causes. Age, time since diagnosis, and physical activity were independent
prognostic factors, which constituted the baseline model along with cancer stage.
When HRQOL domains were tested separately against the baseline model, functional scales
(physical, role, social, and emotional functioning), global health status, symptom scales
(pain and appetite loss), and cervical cancer module items (body image, sexual inactivity,
and sexual worry) were significantly associated with survival (P G 0.05).
Conclusions: These findings suggest that, in addition to well-known prognostic factors,
including age, time since diagnosis, and physical activity, HRQOL scores obtained from
disease-free CCSs are associated with survival.
Keimyung Author(s)(Kor)
조치흠
Publisher
School of Medicine
Citation
Mi-Kyung Kim et al. (2016). Health-Related Quality of Life and Sociodemographic Characteristics as Prognostic Indicators of Long-term Survival in Disease-Free Cervical Cancer Survivors. International Journal of Gynecological Cancer, 26(4), 743–749. doi: 10.1097/IGC.0000000000000665
Type
Article
ISSN
1048-891X
Source
https://insights.ovid.com/pubmed?pmid=26905329
DOI
10.1097/IGC.0000000000000665
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33213
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
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