Insulin and glucagon levels of umbilical cord blood in appropriate for gestational age - preterm infants with or without postnatal hypoglycemia
- Author(s)
- Jin Gon Bae; Shin Kim; Chun Soo Kim; Sang Lak Lee; Heung Sik Kim; Jae Hyun Park
- Keimyung Author(s)
- Park, Jae Hyun; Kim, Chun Soo; Lee, Sang Lak; Kim, Heung Sik; Bae, Jin Gon; Kim, Shin
- Department
- Dept. of Pediatrics (소아청소년학)
Dept. of Obstetrics & Gynecology (산부인과학)
Dept. of Immunology (면역학)
- Journal Title
- Annals of Pediatric Endocrinology & Metabolism.
- Issued Date
- 2016
- Volume
- 21
- Issue
- 2
- Keyword
- Insulin; Glucagon; Fetal blood; Hypoglycemia; Premature infant
- Abstract
- Purpose: To determine whether serum insulin and glucagon levels of umbilical
cord blood correlate with subsequent postnatal hypoglycemia in appropriate for
gestational age (AGA) – preterm infants at different gestational ages (GAs).
Methods: The serum insulin and glucagon levels of umbilical cord blood were
measured using magnetic bead based multiplex immunoassay in 69 AGA -
premature infants, stratified according to GA: GA 23–30 weeks, early preterm
(EP, n=31); GA 31–34 weeks, late preterm (LP, n=38). Postnatal hypoglycemia was
defined as a capillary glucose level <40 mg/dL within the first 60 minutes of life,
regardless of GA.
Results: The capillary glucose concentration in EP infants (65.5±21.2 mg/dL) was
significantly higher than that of LP infants (55.9±17.3 mg/dL) (P=0.043). The serum
glucagon level in EP infants (44.3±28.7 pg/mL) was significantly higher than that
in LP infants (28.1±13.6 pg/mL) (P=0.006). There was not a significant difference in
serum insulin level between EP and LP infants (372.7±254.2 pg/mL vs. 372.4±209.1
pg/mL, P=0.996). There was a significant difference in the serum glucagon level
between infants with and without hypoglycemia (27.7±8.9 mg/dL vs. 36.8±
24.6 mg/dL, P=0.036), but not in the serum insulin level (451.9±256.9 pg/mL vs.
357.4±222.2 pg/mL, P=0.211). Postnatal glucose concentration within the first 60
minutes of life had a significant positive correlation with serum glucagon levels
(r=0.256, P=0.034), but not with serum insulin levels (r=–0.020, P=0.867).
Conclusion: Lower glucagon levels of cord blood were seen in premature
infants with higher GA, which might contribute to the occurrence of postnatal
hypoglycemia.
Keywords: Insulin, Glucagon, Fetal blood, Hypoglycemia, Premature infant
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