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Lupeol Isolated from Sorbus commixta Suppresses 1α,25-(OH)2D3-Mediated Osteoclast Differentiation and Bone Loss in Vitro and in Vivo

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Author(s)
Nam Kyung ImDong-Sung LeeSeong-Ryong LeeGil Saeng Jeong
Keimyung Author(s)
Lee, Seong Ryong
Department
Dept. of Pharmacology (약리학)
Brain Research Institute (뇌연구소)
Journal Title
Journal of Natural Products
Issued Date
2016
Volume
79
Issue
2
Abstract
Lupeol is a lupane-type triterpene isolated from Sorbus commixta, an oriental medicine used to treat arthritis and inflammatory diseases. However, the antiosteoporotic effects of S. commixta or any of its constituents have not been studied yet. In the present study, we have examined the effect of lupeol (a major active triterpenoid isolated from S. commixta) on osteoclastogenesis and sought to elucidate its underlying molecular mechanisms. We evaluated whether lupeol antagonized osteoclast differentiation and bone resorption. Lupeol markedly inhibited osteoclast differentiation and bone resorption activity through its effects on MAP kinases and transcription factors (NF-κB, NFATc1, and c-Fos) downstream of the osteoclast differentiation factor receptor RANK. Furthermore, in vivo efficacy of lupeol was confirmed by using an animal model of hypercalcemic mediated bone loss. Taken together, lupeol showed strong inhibitory effects on osteoclastogenesis. Supplementation with S. commixta and lupeol could be beneficial for bone health or osteoclast-related diseases such as osteoporosis, Paget’s disease, osteolysis associated with periodontal disease, and multiple myeloma.
Keimyung Author(s)(Kor)
이성용
Publisher
School of Medicine
Citation
Nam Kyung Im et al. (2016). Lupeol Isolated from Sorbus commixta Suppresses 1α,25-(OH)2D3-Mediated Osteoclast Differentiation and Bone Loss in Vitro and in Vivo. Journal of Natural Products, 79(2), 412–420. doi: 10.1021/acs.jnatprod.5b01088
Type
Article
ISSN
0163-3864
Source
https://pubs.acs.org/doi/10.1021/acs.jnatprod.5b01088
DOI
10.1021/acs.jnatprod.5b01088
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33235
Appears in Collections:
3. Research Institutues (연구소) > Brain Research Institute (뇌연구소)
1. School of Medicine (의과대학) > Dept. of Pharmacology (약리학)
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