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Mechanism of acute endosulfan intoxication-induced neurotoxicity in Sprague-Dawley rats / Mehanizam akutne neurotoksičnosti u Sprague-Dawley štakora izazvane trovanjem endosulfanom

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Author(s)
Tae-chang JangJung-hee JangKyung-won Lee
Keimyung Author(s)
Jang, Jung Hee
Department
Dept. of Pharmacology (약리학)
Journal Title
Archives of Industrial Hygiene and Toxicology
Issued Date
2016
Volume
67
Issue
1
Keyword
EndosulfanInflammationNeurotoxicityOxidative stress
Abstract
The purpose of this study was to investigate the molecular mechanism underlying oxidative and inflammatory neuronal
cell death induced by endosulfan, a pesticide belonging to the chemical family of organochlorines. The cortical and
hippocampal tissues derived from Sprague-Dawley (SD) rats treated with endosulfan exhibited increased intracellular
accumulation of reactive oxygen species and oxidative damages to cellular macromolecules such as depletion of glutathione,
lipid peroxidation, and protein carbonylation. Conversely, the expression of antioxidant enzymes including
γ-glutamylcysteine ligase (GCL), superoxide dismutase (SOD), and heme oxygenase-1 (HO-1) was markedly reduced
in the brain tissues exposed to endosulfan. Moreover, during endosulfan-induced neuronal cell death, mRNA expression
of pro-inflammatory cytokines such as tumour necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) was elevated, which
seemed to be mediated by the activation of nuclear factor-kappa B (NF-κB) by phosphorylation of p65 subunit. These
results suggest a new molecular mechanism underlying the endosulfan-induced acute neurotoxicity via induction of
oxidative stress and pro-inflammatory responses.
Alternative Title
Mehanizam akutne neurotoksičnosti u Sprague-Dawley štakora izazvane trovanjem endosulfanom
Keimyung Author(s)(Kor)
장정희
Publisher
School of Medicine
Citation
Tae-chang Jang et al. (2016). Mechanism of acute endosulfan intoxication-induced neurotoxicity in Sprague-Dawley rats / Mehanizam akutne neurotoksičnosti u Sprague-Dawley štakora izazvane trovanjem endosulfanom. Archives of Industrial Hygiene and Toxicology, 67(1), 9–17. doi: 10.1515/aiht-2016-67-2702
Type
Article
ISSN
0004-1254
DOI
10.1515/aiht-2016-67-2702
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33237
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pharmacology (약리학)
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