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Oleanolic acid acetate inhibits rheumatoid arthritis by modulating T cell immune responses and matrix-degrading enzymes

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Author(s)
Yeong Su HaJeongsoo YooPil-Hoon ParkTae-Yong ShinTaeg Kyu KwonMun-Chual RhoSang-Hyun KimJin Kyeong ChoiSung-Wan KimDuk-Sil KimcJong Yeong LeeSoyoung LeeHyun-Mee Oh
Keimyung Author(s)
Kwon, Taeg Kyu
Department
Dept. of Immunology (면역학)
Journal Title
Toxicology and Applied Pharmacology
Issued Date
2016
Volume
209
Issue
1
Keyword
Collagen-induced arthritisSynovial fibroblastsOleanolic acid acetateMatrix metalloproteinaseLymph nodesInflammatory cytokine
Abstract
Rheumatoid arthritis (RA) is a chronic autoimmune disease associated with a combination of synovium joint
inflammation, synoviumhyperplasia, and destruction of cartilage and bone. Oleanolic acid acetate (OAA), a compound
isolated from Vigna angularis, has been known to possess pharmacological activities, including antiinflammation
and anti-bone destruction. In this study, we investigated the effects of OAA on RA and the underlying
mechanisms of action by using a type-II collagen-induced arthritis (CIA) mouse model and tumor necrosis
factor (TNF)-α-stimulated RA synovial fibroblasts. Oral administration of OAA decreased the clinical arthritis
symptoms, paw thickness, histologic and radiologic changes, and serum total and anti-type II collagen IgG,
IgG1, and IgG2a levels. OAA administration reduced Th1/Th17 phenotype CD4+ T lymphocyte expansions and inflammatory
cytokine productions in T cell activated draining lymph nodes and spleen. OAA reduced the expression
and production of inflammatory mediators, such as cytokines and matrix metalloproteinase (MMP)-1/3, in
the ankle joint tissue and RA synovial fibroblasts by down-regulating Akt, mitogen-activated protein kinases, and
nuclear factor-κB. Our results clearly support that OAA plays a therapeutic role in RA pathogenesis bymodulating
helper T cell immune responses and matrix-degrading enzymes. The immunosuppressive effects of OAA were
comparable to dexamethasone and ketoprofen.We provide evidences that OAA could be a potential therapeutic
candidate for RA.
Keimyung Author(s)(Kor)
권택규
Publisher
School of Medicine
Citation
Yeong Su Ha et al. (2016). Oleanolic acid acetate inhibits rheumatoid arthritis by modulating T cell immune responses and matrix-degrading enzymes. Toxicology and Applied Pharmacology, 209(1), 1–9. doi: 10.1016/j.taap.2015.11.005
Type
Article
ISSN
0041-008X
Source
https://www.sciencedirect.com/science/article/pii/S0041008X15301320?via%3Dihub
DOI
10.1016/j.taap.2015.11.005
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33246
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
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