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Orthostatic hypertension: An underestimated cause of orthostatic intolerance

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Author(s)
Hyung LeeHyun-Ah Kim
Keimyung Author(s)
Lee, HyungKim, Hyun Ah
Department
Dept. of Neurology (신경과학)
Brain Research Institute (뇌연구소)
Journal Title
Clinical Neurophysiology
Issued Date
2016
Volume
127
Issue
4
Keyword
Orthostatic intoleranceHypertensionBlood pressureAutonomic nervous system diseases
Abstract
Objective: To investigate the frequency and mechanism of orthostatic hypertension (OHT) in patients
with orthostatic intolerance.
Methods: We retrospectively reviewed 1033 consecutive case series of orthostatic intolerance that
underwent autonomic function tests including a head-up tilt test. OHT was defined as a paradoxical
orthostatic increase in systolic blood pressure (BP) of at least 20 mmHg during the tilt. We collected
autonomic parameters during the standardized autonomic function tests, which included the beat-tobeat
derived hemodynamic parameters during the tilt table test and compared them with age and
sex-matched normal controls and the orthostatic hypotension (OH) group with orthostatic symptoms.
Results: We identified 38 (3.7%) patients who showed OHT during the tilt. The increase in mean systolic
BP during the tilt was 26.5 mmHg. Approximately 87% (33/38) of the OHT patients showed an increase in
total peripheral resistance during the tilt. The mean increase in total peripheral resistance from a supine
baseline was significantly higher in OHT patients compared to normal controls, but the OH group showed
a decrease in mean total peripheral resistance during the tilt.
Conclusion: A select few patients with orthostatic dizziness can show OHT during the tilt and they have
signs of increased peripheral resistance.
Significance: OHT may be considered in the differential diagnosis of orthostatic intolerance.
Keimyung Author(s)(Kor)
이형
김현아
Publisher
School of Medicine
Citation
Hyung Lee and Hyun-Ah Kim. (2016). Orthostatic hypertension: An underestimated cause of orthostatic intolerance. Clinical Neurophysiology, 127(4), 2102–2107. doi: 10.1016/j.clinph.2015.12.017
Type
Article
ISSN
1388-2457
Source
https://www.sciencedirect.com/science/article/pii/S138824571600002X?via%3Dihub
DOI
10.1016/j.clinph.2015.12.017
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33250
Appears in Collections:
3. Research Institutues (연구소) > Brain Research Institute (뇌연구소)
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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