계명대학교 의학도서관 Repository

Polymorphisms of the TRPV2 and TRPV3 genes associated with fibromyalgia in a Korean population.

Metadata Downloads
Author(s)
Dong-Jin ParkSeong-Ho KimSeong-Su NahJi Hyun LeeSeong-Kyu KimYeon-Ah LeeSeung-Jae HongHyun-Sook KimHye-Soon LeeHyoun Ah KimChung-Il JoungSang-Hyon KimShin-Seok Lee
Keimyung Author(s)
Kim, Sang Hyon
Department
Dept. of Internal Medicine (내과학)
Journal Title
Rheumatology
Issued Date
2016
Volume
55
Issue
8
Keyword
FibromyalgiaTransient receptor potential vanilloidPolymorphism
Abstract
OBJECTIVE:
Researchers continue to gather evidence that transient receptor potential vanilloid (TRPV) channels contribute towards pain signalling pathways. However, it is unknown whether polymorphisms of the TRPV gene are associated with FM. For the first time, we investigated the association between the polymorphisms of the TRPV2 and TRPV3 genes, FM susceptibility and the severity of the symptoms.

METHODS:
A total of 409 patients with FM and 423 controls were enrolled from 10 medical centres that participated in the Korean nationwide FM survey. The alleles and genotypes at three positions [rs3813768(C > G), rs8121(C > T) and rs1129235(C > A)] in the TRPV2 gene and two positions [rs7216486 (G > A) and rs395357(C > T)] in the TRPV3 gene were genotyped.

RESULTS:
The frequencies of the alleles and genotypes of individual TRPV2 and TRPV3 genes were not significantly associated with FM susceptibility. However, the GTA haplotype of TRPV2 showed a defence against FM susceptibility (P = 0.035). In addition, polymorphisms of TRPV3 were associated with symptom severity in FM patients. The single nucleotide polymorphism rs395357 of TRPV3 was associated with the scores of the Brief Fatigue Inventory (P = 0.017) in FM patients. Furthermore, haplotypes of TRPV3 were associated with the Brief Fatigue Inventory and the 36-item Short-Form Health Survey mental health summary scores (P = 0.036).

CONCLUSION:
This study was the first to evaluate the associations of TRPV gene polymorphisms with FM. Our results suggest that certain TRPV2 haplotypes may have a protective role against FM and that some genotypes and haplotypes of TRPV3 contribute towards the symptoms of FM.
Keimyung Author(s)(Kor)
김상현
Publisher
School of Medicine
Citation
Dong-Jin Park et al. (2016). Polymorphisms of the TRPV2 and TRPV3 genes associated with fibromyalgia in a Korean population. Rheumatology, 55(8), 1518–1527. doi: 10.1093/rheumatology/kew180
Type
Article
ISSN
1462-0324
Source
https://academic.oup.com/rheumatology/article/55/8/1518/2566593
DOI
10.1093/rheumatology/kew180
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33256
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.