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Potential Relationship between Season of Birth and Clinical Characteristics in Major Depressive Disorder in Koreans: Results from the CRESCEND Study

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Author(s)
Seon-Cheol ParkJeong-Kyu SakongBon Hoon KooJae-Min KimTae-Youn JunMin-Soo LeeJung-Bum KimHyeon-Woo YimYong Chon Park
Keimyung Author(s)
Kim, Jung Bum
Department
Dept. of Psychiatry (정신건강의학)
Journal Title
Yonsei medical journal
Issued Date
2016
Volume
57
Issue
3
Keyword
Season of birth (SOB)Major depressive disorder (MDD)Age at onsetDiminished concentrationself-directedness
Abstract
We aimed to examine the potential relationship between season of birth (SOB) and clinical characteristics in Korean patients
with unipolar non-psychotic major depressive disorder (MDD). Using data from the Clinical Research Center for Depression
(CRESCEND) study in South Korea, 891 MDD patients were divided into two groups, those born in spring/summer (n=457) and
those born in autumn/winter (n=434). Measurement tools comprising the Hamilton Depression Rating Scale, Hamilton Anxiety
Rating Scale, Brief Psychiatric Rating Scale, Scale for Suicidal Ideation, Clinical Global Impression of severity, Social and Occupation
Functional Assessment Scale, WHO Quality of Life assessment instrument-abbreviated version, Alcohol Use Disorder Identification
Test, and Temperament and Character Inventory were used to evaluate depression, anxiety, overall symptoms, suicidal
ideation, global severity, social function, quality of life, drinking, and temperament and character, respectively. Using independent
t-tests for continuous variables and χ2 tests for discrete variables, the clinical characteristics of the two groups were compared.
MDD patients born in spring/summer were on average younger at onset of first depressive episode (t=2.084, p=0.038), had
greater loss of concentration (χ2=4.589, p=0.032), and were more self-directed (t=2.256, p=0.025) than those born in autumn/winter.
Clinically, there was a trend for the MDD patients born in spring/summer to display the contradictory characteristics of more
severe clinical course and less illness burden; this may have been partly due to a paradoxical effect of the 5-HT system.
Keimyung Author(s)(Kor)
김정범
Publisher
School of Medicine
Citation
Seon-Cheol Park et al. (2016). Potential Relationship between Season of Birth and Clinical Characteristics in Major Depressive Disorder in Koreans: Results from the CRESCEND Study. Yonsei medical journal, 57(3), 784–789. doi: 10.3349/ymj.2016.57.3.784
Type
Article
ISSN
0513-5796
DOI
10.3349/ymj.2016.57.3.784
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33257
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Psychiatry (정신건강의학)
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