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Predictors of pathologic complete response after preoperative concurrent chemoradiotherapy of rectal cancer: a single center experience

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Author(s)
Euncheol ChoiJin Hee KimOk Bae KimMi Young KimYoung Ki OhSung Gyu Baek
Keimyung Author(s)
Kim, Jin HeeKim, Ok BaeOh, Young KeeBaek, Seong Kyu
Department
Dept. of Radiation Oncology (방사선종양학)
Dept. of Surgery (외과학)
Journal Title
Radiation Oncology Journal
Issued Date
2016
Volume
34
Issue
2
Keyword
RectumRectal neoplasmsChemoradiotherapyStageInterval
Abstract
Purpose: To identify possible predictors of pathologic complete response (pCR) of rectal cancer after preoperative concurrent
chemoradiotherapy (CCRT).
Materials and Methods: We conducted a retrospective review of 53 patients with rectal cancer who underwent preoperative
CCRT followed by radical surgery at a single center between January 2007 and December 2012. The median radiotherapy dose to
the pelvis was 54.0 Gy (range, 45.0 to 63.0 Gy). Five-fluorouracil-based chemotherapy was administered via continuous infusion
with leucovorin.
Results: The pCR rate was 20.8%. The downstaging rate was 66%. In univariate analyses, poor and undifferentiated tumors (p =
0.020) and an interval of ≥7 weeks from finishing CCRT to surgery (p = 0.040) were significantly associated with pCR, while female
gender (p = 0.070), initial carcinoembryonic antigen concentration of <5.0 ng/dL (p = 0.100), and clinical stage T2 (p = 0.100) were
marginally significant factors. In multivariate analysis, an interval of ≥7 weeks from finishing CCRT to surgery (odds ratio, 0.139;
95% confidence interval, 0.022 to 0.877; p = 0.036) was significantly associated with pCR, while stage T2 (odds ratio, 5.363; 95%
confidence interval, 0.963 to 29.877; p = 0.055) was a marginally significant risk factor.
Conclusion: We suggest that the interval from finishing CCRT to surgery is a predictor of pCR after preoperative CCRT in patients
with rectal cancer. Stage T2 cancer may also be an important predictive factor. We hope to perform a robust study by collecting
data during treatment to obtain more advanced results.
Keimyung Author(s)(Kor)
김진희
김옥배
오영기
백성규
Publisher
School of Medicine
Citation
Euncheol Choi et al. (2016). Predictors of pathologic complete response after preoperative concurrent chemoradiotherapy of rectal cancer: a single center experience. Radiation Oncology Journal, 34(2), 106–112. doi: 10.3857/roj.2015.01585
Type
Article
ISSN
2234-1900
DOI
10.3857/roj.2015.01585
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33261
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학)
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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