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Prognostic Significance of 18F-FDG Uptake in Hepatocellular Carcinoma Treated with Transarterial Chemoembolization or Concurrent Chemoradiotherapy: A Multicenter Retrospective Cohort Study

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Author(s)
Do Young KimSeung Up KimDae Hyuk MoonJong Doo Leeand Mijin YunJeong Won LeeJin Kyoung OhYong An ChungSae Jung NaSeung Hyup HyunIl Ki HongJae Seon EoBong-Il SongTae-sung Kim
Keimyung Author(s)
Song, Bong Il
Department
Dept. of Nuclear Medicine (핵의학)
Journal Title
Journal of Nuclear Medicine
Issued Date
2016
Volume
57
Issue
4
Keyword
Hepatocellular carcinomaPrognosis18F-FDG PETTransarterial chemoembolizationConcurrent chemoradiotherapy
Abstract
This study aimed to assess the prognostic value of 18F-FDG uptake in
hepatocellular carcinoma (HCC) patients who had transarterial chemoembolization
(TACE) or concurrent intraarterial chemotherapy with
external-beam radiotherapy (CCRT) and to compare the prognosis
between patients treated with TACE and those with CCRT according
to 18F-FDG uptake. Methods: Two hundred fourteen intermediate–
to–advanced-stage HCC patients without extrahepatic metastasis
who underwent staging 18F-FDG PET/CT before TACE (153 patients)
or CCRT (61 patients) were recruited from 7 hospitals. Progressionfree
survival (PFS) and overall survival (OS) were compared using an
optimal cutoff value for tumor-to-normal liver uptake ratio (TLR). Further,
PFS and OS were compared according to treatment modalities
(TACE vs. CCRT) using the same TLR cutoff value. Results: On
multivariate analysis, age and TLR were independent prognostic
factors for PFS (P , 0.050). For OS, Child–Pugh classification and
TLR were independent prognostic factors (P , 0.050). When the
TLR was greater than 2.0, patients treated with CCRT showed significantly
better PFS and OS than those treated with TACE after
adjusting for tumor size and number (P 5 0.014, for all). In contrast,
there was no significant difference in PFS and OS between patients
treated with TACE or CCRT when the TLR was 2.0 or less.
Conclusion: 18F-FDG uptake was an independent prognostic factor
for PFS and OS in HCC patients treated with TACE or CCRT.
Especially, in HCCs with high 18F-FDG uptake, patients treated
with CCRT showed better survival than those treated with TACE
Keimyung Author(s)(Kor)
송봉일
Publisher
School of Medicine
Citation
Do Young Kim et al. (2016). Prognostic Significance of 18F-FDG Uptake in Hepatocellular Carcinoma Treated with Transarterial Chemoembolization or Concurrent Chemoradiotherapy: A Multicenter Retrospective Cohort Study. Journal of Nuclear Medicine, 57(4), 509–516. doi: 10.2967/jnumed.115.167338
Type
Article
ISSN
0161-5505
Source
http://jnm.snmjournals.org/content/current
DOI
10.2967/jnumed.115.167338
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33265
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학)
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