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Recurrence and Its Impact on the Health-related Quality of Life in Patients with Gastroesophageal Reflux Disease: A Prospective Follow-up Analysis

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Author(s)
Yang Won MinYong Woon ShinGab Jin CheonKyung Sik ParkHyun Soo KimChong-Il SohnTae Nyeun KimHyeung Cheol MoonPoong-Lyul Rhee
Keimyung Author(s)
Park, Kyung Sik
Department
Dept. of Internal Medicine (내과학)
Journal Title
Journal of Neurogastroenterology and Motility
Issued Date
2016
Volume
22
Issue
1
Keyword
Gastroesophageal refluxQuality of lifeRecurrenceTherapy
Abstract
Background/Aims
Limited data exist on the outcome of gastroesophageal reflux disease (GERD) treatment and its impact on the health-related quality
of life (HRQoL) in the Asian population. This study aims to evaluate the treatment outcomes, to investigate the factors associated with
recurrence, and to evaluate the impact of the treatment outcome on the HRQoL in a Korean GERD population.
Methods
This was a prospective, multicenter study involving a total of 824 GERD patients. The response to treatment was assessed at week 4
(or week 8 for the patients who did not achieve complete resolution [CR] at week 4). The EQ-5D questionnaire was used at baseline,
end of treatment, and first recurrence to assess the HRQoL. To assess GERD symptoms, contact of patients by phone at 1, 6, and 12
months following treatment was carried out.
Results
CR was achieved in 65.6% and recurrence was observed in 47.8% following treatment. CR and recurrence rates did not differ by the
presence of esophagitis. Multivariate analysis revealed that acid regurgitation (odds ratio 2.249; 95% confidence interval 1.293-3.912;
P = 0.004) and both acid regurgitation and heartburn (odds ratio 2.330; 95% confidence interval 1.392-3.901; P = 0.001) were
independent risk factors for GERD recurrence. EQ-5D scores were more improved in patients with CR than in those without CR, and
worsened more during follow-up in patients with recurrence than in those without recurrence.
Conclusions
We should achieve complete symptom relief and attempt to prevent recurrence in GERD patients to improve their HRQoL.
Keimyung Author(s)(Kor)
박경식
Publisher
School of Medicine
Citation
Yang Won Min et al. (2016). Recurrence and Its Impact on the Health-related Quality of Life in Patients with Gastroesophageal Reflux Disease: A Prospective Follow-up Analysis. Journal of Neurogastroenterology and Motility, 22(1), 86–93. doi: 10.5056/jnm15124
Type
Article
ISSN
2093-0879
DOI
10.5056/jnm15124
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33274
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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