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Remifentanil-induced preconditioning has cross-talk with A1 and A2B adenosine receptors in ischemic-reperfused rat heart

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Author(s)
Yong-Cheol LeeJiyoon JungSang-Jin Park
Keimyung Author(s)
Lee, Yong Cheol
Department
Dept. of Anesthesiology & Pain Medicine (마취통증의학)
Journal Title
Bosnian Journal of Basic Medical Sciences
Issued Date
2016
Volume
16
Issue
1
Keyword
AdenosineCross-talkRemifentanilReperfusionPreconditioning
Abstract
The purpose of this study was to determine whether there is a cross-talk between opioid receptors (OPRs) and adenosine receptors (ADRs) in remifentanil preconditioning (R-Pre) and, if so, to investigate the types of ADRs involved in the cross-talk. Isolated rat hearts received 30 min of regional ischemia followed by 2 hr of reperfusion. OPR and ADR antagonists were perfused from 10 min before R-Pre until the end of R-Pre. The heart rate, left ventricular developed pressure (LVDP),velocity of contraction (+dP/dtmax), and coronary flow (CF) were recorded. The area at risk and area of necrosis were measured. After reperfusion, the LVDP, +dP/dtmax,and CF showed a significant increase in the R-Pre group compared with the control group (no intervention before or after regional ischemia). These increases in the R-Pre group were blocked by naloxone, a nonspecific ADR antagonist, an A1 ADR antagonist, and an A2B ADR antagonist. The infarct size was reduced significantly in the R-Pre group compared with the control group. The infarct-reducing effect in the R-Pre group was blocked by naloxone, the nonspecific ADR antagonist, the A1 ADR antagonist, and the A2B ADR antagonist. The results of this study demonstrate that there is cross-talk between ADRs and OPRs in R-Pre and that A1 ADR and A2B ADR appear to be involved in the cross-talk.
Keimyung Author(s)(Kor)
이용철
Publisher
School of Medicine
Citation
Yong-Cheol Lee et al. (2016). Remifentanil-induced preconditioning has cross-talk with A1 and A2B adenosine receptors in ischemic-reperfused rat heart. Bosnian Journal of Basic Medical Sciences, 16(1), 64–70. doi: 10.17305/bjbms.2016.738
Type
Article
ISSN
1512-8601
DOI
10.17305/bjbms.2016.738
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33279
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anesthesiology & Pain Medicine (마취통증의학)
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