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Risk Factors for Gallstone Formation in Resected Gastric Cancer Patients

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Author(s)
Kyu-hyun Paikong-Chan LeeHyoung Woo KimJingu KangYoon Suk LeeJin-Hyeok HwangSang Hoon AhnDo Joong ParkHyung-Ho KimJaihwan Kim
Keimyung Author(s)
Lee, Yoon Suk
Department
Dept. of Internal Medicine (내과학)
Journal Title
Medicine
Issued Date
2016
Volume
95
Issue
15
Abstract
Previous studies reported increased incidence of gallstone
formation after gastrectomy.However, therewere fewreports about factors
other than surgical technique. The purpose of this study is to investigate the
spectrum of risk factors of gallstone formation after gastrectomy.
From June 2003 to December 2008, 1480 patients who underwent
gastrectomy due to gastric cancer but had no gallstones before surgery
were identified. Electronic medical records were retrospectively
reviewed. Gallstones were assessed by computerized tomography or
ultrasound performed as surveillance for recurrence.
There were 987 men (66.7%) and themedian age was 59.0 years. The
median follow-up period was 47.0 months. According to the surgical
technique, 754 (50.9%), 459 (31.1%), and 267 (18.0%) underwent subtotal
gastrectomy with Billroth I (STG B-I) and Billroth II (STG B-II)
anastomosis, and total gastrectomy (TG). Within the follow-up period,
gallstone formation occurred in 106 of 1480 patients (7.2%), the only 9
patients (0.6%) experienced symptomatic cholecystitis. By multivariate
Cox regression analysis, age (HR 1.02, 95% CI 1.00–1.04), male (1.65,
1.02–2.67), diabetes mellitus (2.15, 1.43–3.24), 4% decrease of body
mass index after surgery (1.66, 1.02–2.70), STG B-II (1.63, 1.03–2.57),
and TG (2.35, 1.43–3.24) compared with STG B-I were associated with
gallstone formation. Common bile duct stone formation occurred in 20 of
1480 patients (1.4%) and was only associated with gallstones.
After gastrectomy, there were considerable numbers of patients with
newly developed gallstones; however, prophylactic cholecystectomy
should not be routinely recommended. Gastrectomy (STG B-II or
TG), old age, male sex, diabetes mellitus, and decreased body mass
index were associated with gallstones.
Keimyung Author(s)(Kor)
이윤석
Publisher
School of Medicine
Citation
Kyu-hyun Paik et al. (2016). Risk Factors for Gallstone Formation in Resected Gastric Cancer Patients. Medicine, 95(15), e3157–e3157. doi: 10.1097/MD.0000000000003157
Type
Article
ISSN
0025-7974
DOI
10.1097/MD.0000000000003157
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33284
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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