계명대학교 의학도서관 Repository

Segmental assessments of coronary plaque morphology and composition by virtual histology intravascular ultrasound and fractional flow reserve

Metadata Downloads
Author(s)
Ju-Hyun ChungSoe Hee AnnGillian Balbir SinghChang-Wook NamJoon-Hyung DohHyung Il KimBon-Kwon KooEun-Seok Shin
Keimyung Author(s)
Nam, Chang Wook
Department
Dept. of Internal Medicine (내과학)
Journal Title
International Journal of Cardiovascular Imaging
Issued Date
2016
Volume
32
Issue
3
Keyword
Fractional flow reserveVirtual histology intravascular ultrasoundPlaque compositionCoronary artery diseaseSegmental analysis
Abstract
Fractional flow reserve (FFR) is an index for
identifying functionally significant stenotic lesions. A FFR
value of B0.75 is considered clinically significant and
indicative of physiological ischemia. Focal lesions with
30–80 % stenosis by angiography with lesion lengths of
less than 20 mm were selected from left anterior
descending arteries of 74 patients. The analysis for the total
lesion was processed first, and then each lesion was divided
into three segments to assess the each segment. Data on
plaque geometry and composition of two FFR groups,
FFR B 0.75 and FFR[0.75, were compared by total and
segmental analysis. Lesions with FFR B 0.75 had more
fibrofatty tissue (13.5 ± 7.4 vs. 10.2 ± 6.5 %, p = 0.05)
and less dense calcium (7.2 ± 5.3 vs. 11.9 ± 7.5 %,
p = 0.01) compared to lesions with FFR[0.75.
content of necrotic core in mid segments was higher
compared to proximal and distal segments (22.9 ± 10.6,
20.2 ± 10.9, 17.1 ± 11.2 %, respectively, p = 0.032) in
lesions with FFR[0.75 but the difference was less obvious
in lesions with FFR B 0.75 (17.9 ± 9.9, 18.7 ± 9.9,
15.8 ± 9.0 %, respectively, p = 0.533). Coronary lesions
with FFR[0.75 have larger content of dense calcium and
slightly less fibrofatty tissue compared to lesions with
FFR B 0.75. While segmental plaque compositions for
each segment show noticeable variations in lesions with
FFR[0.75 such as high concentrations of necrotic core in
mid segment, these differences in each segment become
obscure in FFR B 0.75 and are evenly distributed across
the lesion.
Keimyung Author(s)(Kor)
남창욱
Publisher
School of Medicine
Citation
Ju-Hyun Chung et al. (2016). Segmental assessments of coronary plaque morphology and composition by virtual histology intravascular ultrasound and fractional flow reserve. International Journal of Cardiovascular Imaging, 32(3), 373–380. doi: 10.1007/s10554-015-0794-8
Type
Article
ISSN
1569-5794
Source
http://lps3.link.springer.com.proxy.dsmc.or.kr/article/10.1007%2Fs10554-015-0794-8
DOI
10.1007/s10554-015-0794-8
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33288
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.