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Significance of histologic tumor grade in rectal cancer treated with preoperative chemoradiotherapy followed by curative surgery: A multi-institutional retrospective study

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Author(s)
Jin Ho SongSung Hwan KimJong Hoon LeeHyeon Min ChoDae Yong KimTae Hyun KimSun Young KimJi Yeon BaekJae Hwan OhTaek Keun NamMee Sun YoonJae Uk JeongKyubo KimEui Kyu ChieHong Seok JangJae Sung KimJin Hee KimKi Mun Kang
Keimyung Author(s)
Kim, Jin Hee
Department
Dept. of Radiation Oncology (방사선종양학)
Journal Title
Radiation oncology
Issued Date
2016
Volume
118
Issue
2
Keyword
GradeHistologyNeoplasmPrognosisRectum
Abstract
Background and purpose: To evaluate the pre-treatment clinical factors affecting recurrence and survival
in rectal cancer patients who receive preoperative chemoradiotherapy (CRT) and curative surgery.
Methods and materials: The clinical data of 1782 patients from 8 institutions in Korea were analyzed. The
potential prognostic factors that could be acquired before radical surgery were patient age, gender, clinical
T and N stages, tumor size and location, tumor grade, carcinoembryonic antigen (CEA) level, and the
concurrent chemotherapy regimen. The relapse-free survival (RFS), overall survival (OS), and cumulative
incidence of locoregional and distant recurrence were analyzed according to the clinical factors.
Results: Among the pre-treatment clinical factors, tumor grade, pre-CRT CEA level, tumor location, and
clinical N stage were significant prognostic factors affecting the RFS. The high-grade tumor was the hazardous
factor for RFS on the multivariate analysis [Hazard ratio (HR), 1.83; 95% confidence interval (CI),
1.29–2.58; p = 0.001]. The 5-year RFS rate for high-grade tumors was significantly lower than that for
low-grade tumors (63.8% vs. 78.8%, p < 0.001). The tumor grade was a significant prognostic factor for distant
recurrence (HR, 1.83, 95% CI, 1.29–2.58; p < 0.001), but not for locoregional recurrence (HR, 1.49, 95%
CI, 0.68–3.26; p = 0.320) on the multivariate analysis. The 5-year OS rate for high-grade tumors was significantly
lower than that for low-grade tumors (70.6% vs. 85.5%, p < 0.001).
Conclusion: The tumor grade is the significant pre-treatment clinical factor for recurrence and survival in
rectal cancer patients who receive preoperative CRT and curative surgery.
Keimyung Author(s)(Kor)
김진희
Publisher
School of Medicine
Citation
Jin Ho Song et al. (2016). Significance of histologic tumor grade in rectal cancer treated with preoperative chemoradiotherapy followed by curative surgery: A multi-institutional retrospective study. Radiation oncology, 118(2), 387–392. doi: 10.1016/j.radonc.2015.11.028
Type
Article
ISSN
1748-717X
Source
http://lps3.www.sciencedirect.com.proxy.dsmc.or.kr/science/article/pii/S0167814015006489?via%3Dihub
DOI
10.1016/j.radonc.2015.11.028
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33291
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학)
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