The Association between Urine Albumin to Creatinine Ratio and Osteoporosis in Postmenopausal Women with Type 2 Diabetes
- Affiliated Author(s)
- 조호찬
- Alternative Author(s)
- Cho, Ho Chan
- Journal Title
- Journal of Bone Metabolism
- ISSN
- 2287-6375
- Issued Date
- 2016
- Keyword
- Albumins; Creatinine; Diabetes mellitus type 2; Osteoporosis postmenopausal
- Abstract
- Background: Osteoporosis is a progressive bone disease that is characterized by a decrease in bone mass density and destruction of microstructure, which can lead to an increased risk of fracture. Although many studies have been published about the relationship between end-stage renal disease and osteoporosis, research on the relationship between proteinuria and the prevalence of osteoporosis is still lacking. Methods: We assessed 91 postmenopausal women with type 2 diabetes who visited our hospital from January 2009 to January 2012. Results: Among 91 patients, the prevalence of osteoporosis and osteopenia was 35.2% (32 cases) and 32.9% (30 cases) according to bone mineral density. The patients with microalbuminuria and macroalbuminuria (urine albumin-to-creatinine ratio [UACR] ≥ 30) had a significantly higher incidence of osteoporosis compared to subjects with normoalbuminuria (P<0.05). Conclusions: This study indicates that UACR may be a useful biomarker for increased risk of osteoporosis in postmenopausal women with type 2 diabetes who have been linked to higher UACR levels.
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