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The clinical impact of thalidomide maintenance after autologous stem cell transplantation in patients with newly diagnosed multiple myeloma in real clinical practice of Korea.

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Author(s)
Ho Sup LeeChang-Ki MinJe-Jung LeeKihyun KimSeok Jin KimDok Hyun YoonHyeon-Seok EomHyewon LeeWon Sik LeeHo-Jin ShinJi Hyun LeeYong ParkJae-Cheol JoYoung Rok DoYeung-Chul MunMark Hong LeeThe Korean Multiple Myeloma Working Party
Keimyung Author(s)
Do, Young Rok
Department
Dept. of Internal Medicine (내과학)
Journal Title
Annals of Hematology
Issued Date
2016
Volume
95
Issue
6
Keyword
Multiple myelomaThalidomideTransplantationMaintenanceSurvival
Abstract
In real clinical settings (not clinical trials), thalidomide
has been accepted as maintenance therapy to patients
with multiple myeloma (MM) because of the cost of drugs,
the limitations of medical insurance, etc., in our country
(South Korea). The purpose of this study was to evaluate the
utility of thalidomide maintenance for improving survival in
transplantation-eligible patients with MM in the real clinical
field. Differences in survival rates were estimated in patients
treated with or without thalidomide maintenance. The 3-year
progression-free survival rates (PFS) of patients with and
without maintenance, respectively, were 55.4 and 37.2 %
(p =0.005). The 3-year overall survival rates (OS) were 88.0
and 84.0 % (p = 0.105). No difference in 3-year OS after
relapse or progression (OS2) was observed between the two
groups (50.4 and 55.3 %, p =0.661). The 3-year PFS of patients
with and without maintenance therapy who had shown
less than CR after ASCTwere 68.4 and 23.3 % (p<0.001). In
conclusion, Thalidomide maintenance therapy showed longer
PFS in real clinical practice, and long-term use of thalidomide
did not interfere with the efficacy of salvage chemotherapy in
patients who experienced progression or relapse after ASCT.
In addition, thalidomide maintenance might be also useful for
patients who have shown less than CR after ASCT.
Keimyung Author(s)(Kor)
도영록
Publisher
School of Medicine
Citation
Ho Sup Lee et al. (2016). The clinical impact of thalidomide maintenance after autologous stem cell transplantation in patients with newly diagnosed multiple myeloma in real clinical practice of Korea. Annals of Hematology, 95(6), 911–919. doi: 10.1007/s00277-016-2660-8
Type
Article
ISSN
0939-5555
Source
https://link.springer.com/article/10.1007%2Fs00277-016-2660-8
DOI
10.1007/s00277-016-2660-8
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33305
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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