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The effect of sevoflurane versus desflurane on postoperative catheter-related bladder discomfort in patients undergoing transurethral excision of a bladder tumour: a randomized controlled trial

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Author(s)
Hyun-Chang KimWon-Pyo HongYoung-Jin LimHee-Pyoung Park
Keimyung Author(s)
Kim, Hyun Chang
Department
Dept. of Anesthesiology & Pain Medicine (마취통증의학)
Journal Title
Canadian Journal of Anesthesia
Issued Date
2016
Volume
63
Issue
5
Abstract
Purpose Catheter-related bladder discomfort (CRBD)
due to an indwelling urinary catheter can cause
postoperative distress, and the mechanism underlying
CRBD is linked to the activation of muscarinic receptors.
Inhalation of anesthetic agents, such as sevoflurane and
desflurane, has differential inhibitory effects on muscarinic
receptors. We aimed to compare the effect of intraoperative
sevoflurane vs desflurane inhalation on postoperative
CRBD.
Methods Eighty-nine patients undergoing transurethral
resection of a bladder tumour (TURBT) were randomly
allocated to two groups. The sevoflurane group (n = 45)
and the desflurane group (n = 44) received the respective
inhalational agents for maintenance of general anesthesia.
The incidence and severity (mild/moderate/severe) of
CRBD were assessed at zero, one, six, and 24 hr
postoperatively.
Results Catheter-related bladder discomfort during the
first 24 hr postoperatively occurred in 34/45 (76%) patients
receiving sevoflurane compared with 41/44 (93%) patients
receiving desflurane [absolute difference 18%; 95%
confidence interval [CI], 2 to 33; P = 0.039]. The
differences in the rate of CRBD between the sevoflurane
and desflurane groups at zero, one, and six hours
postoperatively were 24% (95% CI, 7 to 40; P = 0.012),
33% (95% CI, 15 to 49; P = 0.001), and 26% (95% CI, 6 to
43; P = 0.019), respectively. The incidence of moderate to
severe CRBD and the number of patients treated with
tramadol for CRBD were comparable between the two
groups.
Conclusions As a maintenance agent of general
anesthesia, sevoflurane reduced the incidence of early
postoperative CRBD in patients undergoing TURBT when
compared with desflurane. The protocol for this clinical
trial was registered at ClinicalTrials.
Alternative Title
Effet du se´voflurane compare´ au desflurane sur l’inconfort lie´ a` la
sonde ve´sicale en pe´riode postope´ratoire chez les patients
subissant l’excision transure´trale d’une tumeur a` la vessie: une
e´tude randomise´e controˆle´e
Keimyung Author(s)(Kor)
김현창
Publisher
School of Medicine
Citation
Hyun-Chang Kim et al. (2016). The effect of sevoflurane versus desflurane on postoperative catheter-related bladder discomfort in patients undergoing transurethral excision of a bladder tumour: a randomized controlled trial. Canadian Journal of Anesthesia, 63(5), 596–602. doi: 10.1007/s12630-016-0600-7
Type
Article
ISSN
0832-610X
Source
http://lps3.link.springer.com.proxy.dsmc.or.kr/article/10.1007%2Fs12630-016-0600-7
DOI
10.1007/s12630-016-0600-7
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33307
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anesthesiology & Pain Medicine (마취통증의학)
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