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The Efficacy and Safety of Clonazepam in Patients with Anxiety Disorder Taking Newer Antidepressants: A Multicenter Naturalistic Study

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Author(s)
Sheng-Min WangJung-Bum KimJeong Kyu SakongHo-Suk SuhKang Seob OhJong-Min WooSang-Woo YooSang Min LeeSang-Yeol LeeSe-Won LimSeong Jin ChoIk-Seung CheeJeong-Ho ChaeJin Pyo HongKyoung-Uk Lee
Keimyung Author(s)
Kim, Jung Bum
Department
Dept. of Psychiatry (정신건강의학)
Journal Title
Clinical Psychopharmacology and Neuroscience
Issued Date
2016
Volume
14
Issue
2
Keyword
Anti-anxiety agentsAlprazolamClonazepamLorazepamTherapyAnxiety disorders
Abstract
Objective: This study compared the efficacy and tolerability of clonazepam with other benzodiazepines in patients with anxiety
disorders.
Methods: Inclusion criteria were as follows: age >20 years, diagnosis of anxiety disorder according to the Diagnostic and
Statistical Manual of Mental Disorders 4th edition, text revision (DSM-IV-TR) criteria, taking only one type of antidepressant,
and prescribed one of three oral benzodiazepines (alprazolam, clonazepam, or lorazepam). At baseline and week 6, clinical
benefit was evaluated using the Clinical Global Impression-Severity Scale (CGI-S), Clinical Global Impression-Anxiety Scale
(CGI-anxiety), and Clinical Global Impression-Sleep Scale (CGI-sleep).
Results: Among 180 patients, no differences in demographic characteristics among the three benzodiazepine groups were noted.
After six weeks of treatment, all benzodiazepine groups showed significant improvements in CGI-S, CGI-anxiety, and CGI-sleep
scores (p<0.001). There were no differences in mean changes in CGI-S, CGI-anxiety and CGI-sleep among the three benzodiazepine
groups. The incidence of side effects was significantly lower in the clonazepam group than with the other benzodiazepines.
The incidences of adverse events for the clonazepam, alprazolam, and lorazepam groups were 26.7% (n=20), 48.4% (n=31),
and 43.9% (n=18), respectively.
Conclusion: The present study suggests that clonazepam is as efficacious as other benzodiazepines for the treatment of various
anxiety disorders. Furthermore, the safety profile of clonazepam was superior to the other benzodiazepines in this study.
Keimyung Author(s)(Kor)
김정범
Publisher
School of Medicine
Citation
Sheng-Min Wang et al. (2016). The Efficacy and Safety of Clonazepam in Patients with Anxiety Disorder Taking Newer Antidepressants: A Multicenter Naturalistic Study. Clinical Psychopharmacology and Neuroscience, 14(2), 177–183. doi: 10.9758/cpn.2016.14.2.177
Type
Article
ISSN
1738-1088
DOI
10.9758/cpn.2016.14.2.177
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33308
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Psychiatry (정신건강의학)
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