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The need for histological subclassification of cirrhosis: a systematic review and meta-analysis

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Author(s)
Gaeun KimSamuel S. LeeSoon Koo BaikYoun Zoo ChoMoon Young KimSang Ok KwonSeung Hwan ChaMee Yon Cho
Keimyung Author(s)
Kim, Ga Eun
Department
Dept. of Nursing (간호학)
Research Institute for Nursing Science (간호과학연구소)
Journal Title
Liver International
Issued Date
2016
Volume
36
Issue
6
Keyword
CcirrhosisLaennec stageSystematic review and meta-analysis
Abstract
Background & Aims: The need for further histological subclassification of cirrhosis has been increasingly recognized
because of the heterogeneity of severity within cirrhosis. We sought to identify evidence in the literature regarding the histological
subclassification of cirrhosis using the Laennec stage. Methods: We conducted a systematic review and meta-analysis
by searching databases, including MEDLINE, EMBASE and the COCHRANE library, for relevant studies. Results: Of 208
studies identified, 16 were eligible according to the inclusion criteria. With higher grades of the Laennec stage, clinical stages
of cirrhosis and Child–Pugh scores/Model for end-stage liver disease scores increased (P < 0.05). Higher Laennec stages were
statistically associated with the development of liver-related events, such as liver-related death, liver cancer progression and
variceal haemorrhage, as well as higher hepatic venous pressure gradients and higher liver stiffness values (P < 0.05). Two
open-labelled studies showed the usefulness of the Laennec system with regard to the evaluation of whether antifibrotic
treatments were effective. The mean kappa value was 0.81 (range 0.61–0.87) for inter-observer agreement. Conclusions:
Based on this systematic review and meta-analysis, histological subclassification of cirrhosis using the Laennec system is useful
to better predict prognosis and complications of portal hypertension.
Keimyung Author(s)(Kor)
김가은
Publisher
College of Nursing
Citation
Gaeun Kim et al. (2016). The need for histological subclassification of cirrhosis: a systematic review and meta-analysis. Liver International, 36(6), 847–855. doi: 10.1111/liv.12923
Type
Article
ISSN
1478-3223
Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/liv.12923
DOI
10.1111/liv.12923
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33312
Appears in Collections:
2. College of Nursing (간호대학) > Dept. of Nursing (간호학)
3. Research Institutues (연구소) > Research Institute for Nursing Science (간호과학연구소)
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