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Topographic correlation between optic nerve head characteristics and retinal nerve fibre layer defect in primary open-angle glaucoma patients: Korea National Health and Nutrition Examination Survey

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Affiliated Author(s)
이종은
Alternative Author(s)
Lee, Chong Eun
Journal Title
Acta Ophthalmologica
ISSN
1755-375X
Issued Date
2016
Keyword
Primary open-angle glaucomaPeripapillary atrophyOptic disc torsionRetinal nerve fiber layer defectKorea National Health and Nutrition Examination Survey
Abstract
Purpose: To evaluate topographi c correlations of the directions of b-zone
peripapillary atrophy (PPA) and optic disc torsion with retinal nerve fibre layer
(RNFL) defect in a Korean population.
Methods: Among 292 primary open-angle glaucoma (POAG) patients from the
2012 KNHANES (n = 7444, age ≥ 19 years), 93 eyes of 93 individuals with a single
localized RNFL defect were enrolled. The angular locations of the point of maximum
radial extent (PMRE) of b-zone PPA and the optic disc torsion were measured on
fundus photography. The angular location of the PMRE and the torsion degree (TD)
were noted when the absolute value of the former or the latter was ≥15 degrees from
the reference line, a line drawn from the centre of the optic disc to the fovea.
Results: The overall POAG prevalence was estimated as 4.2% (95% confidence
interval [CI], 3.6– 4.9). Of the POAG eyes with a single localized RNFL defect,
39.5% had superior or inferior PMRE of b-zone PPA; in 74.9% (p = 0.015) of
those cases, the RNFL defect was located in the same hemifield as the angular
location of the PMRE. Meanwhile, 40.4% of the POAG eyes with a single
localized RNFL defect showed accompanying optic disc torsion. The correlation
rate between the direction of the optic disc torsion and the RNFL defect location
was 60.2% (p = 0.029).
Conclusions: In the Korean POAG patients examined, the directions of the
PMRE of b-zone PPA and of the optic disc torsion showed significant
associations with the RNFL defect location.
Department
Dept. of Ophthalmology (안과학)
Publisher
School of Medicine
Citation
Chong Eun Lee et al. (2016). Topographic correlation between optic nerve head characteristics and retinal nerve fibre layer defect in primary open-angle glaucoma patients: Korea National Health and Nutrition Examination Survey. Acta Ophthalmologica, 94(2), e98–e104. doi: 10.1111/aos.12855
Type
Article
ISSN
1755-375X
DOI
10.1111/aos.12855
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33318
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Ophthalmology (안과학)
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