조현병 환자에서 음성증상과 사회인지의 연관성

Abstract

Objectives：Although negative symptoms play important role in daily functioning of patients with schizophrenia, it remains unclear which symptoms clearly related to each other, and whether these symptoms develop sequentially or simultaneously. The current study examined negative and positive symptoms along with social cognition ability, to determine which symptoms are more strongly correlated. We also examined two subdomains of negative symptom, motivation/ pleasure and expression, to investigate which subdomain has more strong correlation with social cognition. Methods：120 patients with schizophrenia were enrolled from three different hospitals. All patients were evaluated with Scale for the Assessment of Negative Symptoms(SANS), Positive And Negative Symptom Scale(PANSS), Clinical Assessment Interview for Negative Symptoms(CAINS), Korean Facial Expressions of Emotion(KOFEE) and Eyes task. Correlation analysis, structural equation modeling(SEM), and stepwise regression analysis were used to analyze data. Results：Social cognition was significantly correlated with negative symptoms rather than positive symptoms. Eyes task was negatively correlated with CAINS total score and both two subdomains. Although Eyes task was a significant predictor for both subscales of CAINS, it had more explanatory power for motivation/pleasure subdomain than expression subdomain. The results of SEM, model that KOFEE effects Eyes task and Eyes task effects each negative symptoms, motivation/pleasure, expression indicated most good fit. Conclusion：These findings confirmed the hypothesized relations that social cognition has more strong correlation with negative symptoms rather than positive symptoms. In addition these results provide empirical support for pathway which reduced social cognition ability impacts on developing negative symptoms.