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Structural Variations of the Prostatic Urethra Within the Prostate Predict the Severities of Obstructive Symptoms : A Prospecitve Mulitcenter Observaitonal Study

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Author(s)
Young Hwii KoTae-Hwan KimPhil Hyun SongByung Hoon KimBum Soo KimKi Ho KimJaeho Cho
Keimyung Author(s)
Kim, Byung Hoon
Department
Dept. of Urology (비뇨의학)
Journal Title
Urology
Issued Date
2017
Volume
140
Issue
1
Abstract
Objective;To describe distinctive morphologic variations of the prostate associated with the prostatic urethra, and to determine whether structural changes of the urethra within the prostate resulting from gland enlargement, rather than prostrate volume itself, lead to male lower urinary tract symptom (LUTS).
Materials and Methods;After standardizing measurements, 7 ultrasonography-determined variables, that is, prostate volume, transitional zone volume, transitional zone-to-total volume ratio, presence of intraprostatic protrusion, prostatic urethral angle, prostatic urethral length (PUL), and PUL-to-volume ratio (rPUL), were obtained prospectively in 293 men who had not taken LUTS medication during the 3 months prior to initial visits. Correlations between these variables and international prostate symptom scores (IPSS) were then investigated.
Results;By simple correlation, only rPUL showed a significant association with IPSS. Multiple linear regression revealed IPSS were significantly correlated with age (beta = .179, P = .04) and rPUL (beta = .139, P = .019). Subanalysis with respect to the symptoms of IPSS revealed only rPUL was correlated with voiding symptoms (Q1,3,5,6; beta = .122, P = .036), and that age alone was correlated with storage symptoms (Q2,4,7; beta = .262, P < .001). When dividing 4 groups by applying mean cut-offs for PUL (62 mm) and prostate volume (30 g), long PUL with small volume had significantly higher IPSS score than short PUL with large volume (P = .042).
Conclusion;Structural differences of prostate related to prostatic urethra as reflected by rPUL were found to be significantly correlated with the severity of voiding symptoms. This finding suggests structural change of the prostatic urethra inducted by prostate enlargement underlies the development of male LUTS.
Keimyung Author(s)(Kor)
김병훈
Publisher
School of Medicine
Citation
Young Hwii Ko et al. (2017). Structural Variations of the Prostatic Urethra Within the Prostate Predict the Severities of Obstructive Symptoms : A Prospecitve Mulitcenter Observaitonal Study. Urology, 140(1), 160–165. doi: 10.1016/j.urology.2017.03.014
Type
Article
ISSN
0090-4295
Source
https://www.sciencedirect.com/science/article/pii/S0090429517302650?via%3Dihub
DOI
10.1016/j.urology.2017.03.014
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33385
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Urology (비뇨의학)
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