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A nationwide seroepidemiology of hepatitis C virus infection in South Korea

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Author(s)
Do Young KimIn Hee KimSook-Hyang JeongYong Kyun ChoJoon Hyoek LeeYoung-Joo JinDon LeeDong Jin SuhKwang-Hyub HanNeung Hwa ParkHa Yan KangYoung Kul JungYoung Seok KimKyung-Ah KimYoun Jae LeeByung Seok LeeHyung Joon YimHeon Ju LeeSoon Koo BaikWon Young TakSun Jae LeeWoo Jin ChungSung-Kyu ChoiEun-Young ChoJeong HeoDong Joon KimMan Woo KimJun LeeHee Bok ChaeDae Hee ChoiByung-Cheol SongHwa Young ChoiMoran Ki
Keimyung Author(s)
Chung, Woo Jin
Department
Dept. of Internal Medicine (내과학)
Journal Title
Liver International
Issued Date
2013
Volume
33
Issue
4
Keyword
hepatitis C virusinfectionKoreaprevalence
Abstract
Background & Aims
The aim of this study was to reveal nationwide seroprevalence of HCV infection in South Korea by a large-scale survey.

Methods
From January to December 2009, a total of 291 314 adults underwent health check-up in 29 centres nationwide. The data concerning anti-HCV antibody and biochemical tests were obtained from all participants. Among subjects with positive anti-HCV, such data as HCV RNA, genotypes and treatment detail were additionally analysed.

Results
Using an estimated 2009 population of Korea, the age, sex and area-adjusted anti-HCV positive rate was 0.78%. Anti-HCV prevalence in female patients (0.83%) was higher than that in male patients (0.75%). Gradual increase in anti-HCV positivity was observed, from 0.34% in those aged 20–29 years to 2.31% in those >70 years. The age- and sex-adjusted anti-HCV prevalence varied in different areas, being higher in Busan and Jeonnam (1.53–2.07%), mid-level in Seoul and surrounding districts (0.50–0.61%) and lower in Jeju (0.23%). The comparative analysis of laboratory variables between anti-HCV (+) and anti-HCV (−) group revealed significantly higher levels of alanine aminotransferase and lower levels of serum lipids in anti-HCV (+) group. Among 1 718 anti-HCV positive subjects, serum HCV RNA was measured only in 478 people, of whom 268 (56.1%) patients had detectable HCV RNA in serum. Among 50 patients for whom assessment of response to antiviral therapy was feasible, overall sustained virological response was achieved in 84% of patients.

Conclusion
The prevalence of HCV infection is low in South Korea. Studies to analyse risk factors are warranted to reduce HCV infection.

Keywords:
hepatitis C virus;
infection;
Korea;
prevalence
Keimyung Author(s)(Kor)
정우진
Publisher
school of Medicine
Citation
Do Young Kim et al. (2013). A nationwide seroepidemiology of hepatitis C virus infection in South Korea. Liver International, 33(4), 586–594. doi: 10.1111/liv.12108
Type
Article
ISSN
1478-3223
Source
http://onlinelibrary.wiley.com/doi/10.1111/liv.12108/epdf
DOI
10.1111/liv.12108
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33395
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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