계명대학교 의학도서관 Repository

A multicenter retrospective cohort study of practice patterns and clinical outcome on radiotherapy for hepatocellular carcinoma in Korea

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Author(s)
Jinsil SeongIk Jae LeeSu Jung ShimDo Hoon LimTae Hyun KimJong Hoon KimHong Seok JangMi Sook KimEui Kyu ChieJin Hee KimTaek-Keun NamHyung Sik LeeChul Joo Han
Keimyung Author(s)
Kim, Jin Hee
Department
Dept. of Radiation Oncology (방사선종양학)
Journal Title
Liver International
Issued Date
2009
Volume
29
Issue
2
Keyword
hepatocelluar carcinomapractice patternradiotherapy
Abstract
Aim: To determine the national practice processes of care and outcomes of radiotherapy for hepatocellular carcinoma (HCC) in Korea.


Patients and Methods: A national survey of 53 institutions nationwide was conducted by requesting data on their experience of radiotherapy for HCC. Among them, 10 institutions were selected for performing more detailed analysis, based on the radiotherapy experience of at least five HCC patients between 2004 and 2005.


Results: This study covered the treatment of 398 HCC patients for 2 years. Most patients (78%) were in stage III or IV. Radiotherapy was chosen after the failure of other treatments, most frequently transarterial chemoembolization. Radiotherapy was performed predominantly using the three-dimensional conformal technique (3D-CRT, 81.9%) mostly with a total dose of ≥45 Gy. In 9.3% of the patients, radiotherapy was performed using radiosurgery. In a biologically effective dose (BED) with 10 Gy of α/β, 4.2–124.3 Gy10 was delivered. The median survival time was 12 months, and the 2-year overall survival rate was 27.9%. A tumour size <5 cm, a negative lymph node and BED >53.1 Gy10 were shown by multivariate analysis to be significant factors for a better prognosis. In a subset analysis for the 326 patients treated with 3D-CRT, better liver function with Child–Pugh class A was shown to be an additional factor for a better prognosis.


Conclusions: Radiotherapy has been used to treat advanced HCC in various modes, but mostly as a salvage treatment. Although this study was retrospective, it indicates that radiotherapy is a quite effective modality for HCC patients.

Keywords:

hepatocelluar carcinoma;
practice pattern;
radiotherapy
Keimyung Author(s)(Kor)
김진희
Publisher
School of Medicine
Citation
Jinsil Seong et al. (2009). A multicenter retrospective cohort study of practice patterns and clinical outcome on radiotherapy for hepatocellular carcinoma in Korea. Liver International, 29(2), 147–152. doi: 10.1111/j.1478-3231.2008.01873.x
Type
Article
ISSN
1478-3223
Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1478-3231.2008.01873.x
DOI
10.1111/j.1478-3231.2008.01873.x
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33397
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학)
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