계명대학교 의학도서관 Repository

A 12-Week, Open Label, Multi-Center Study to Evaluate the Clinical Efficacy and Safety of Silodosin on Voiding Dysfunction in Patients with Neurogenic Bladder

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Author(s)
Kyung Hyun MOONChoal-Hee PARKHee-Chang JUNGTae-Hee OHJae-Soo KIMDuk-Yoon KIM
Keimyung Author(s)
Park, Choal Hee
Department
Dept. of Urology (비뇨의학)
Journal Title
Low Urin Tract Symptoms
Issued Date
2015
Volume
7
Issue
1
Keyword
efficacyneurogenic bladdersilodosin
Abstract
Objectives
The purpose of this study is to evaluate clinical effect and safety of α1A-adrenoceptor blocker, silodosin, in patients with voiding dysfunction caused by neurogenic bladder.

Methods
From April 2011 to January 2012, patients who were diagnosed as potential voiding dysfunction associated with neurogenic bladder, aged ≥ 20 years were enrolled. Silodosin (8 mg/day) was administered once daily in the morning with food. The efficacy was assessed at the baseline and after 12 weeks of the treatment having following parameters of international prostate symptom score and other measures including the maximum flow rate and the postvoid residual urine volume.

Results
A total of 97 patients were screened and 95 were enrolled. Of these 95 patients, 82 patients were completed and included in analysis. After 12-weeks of treatment, mean total international prostate symptom score decreased significantly from 22.23 ± 6.80 to 14.98 ± 9.48 (P = 0.0002). Voiding symptoms and storage symptoms were also improved by decreasing in international prostate symptom score-QoL from 4.62 ± 0.92 to 3.48 ± 1.63 (P < 0.0001). Maximum flow rate increased significantly from 10.72 ± 2.66 to 15.14 ± 6.63 (P < 0.0001). The main adverse event was ejaculation disorder. No serious adverse events related to silodosin were noted.

Conclusions
This study indicates that silodosin was significantly effective, well tolerated and safe in patients who have voiding dysfunction associated with neurogenic bladder.
Keywords:

efficacy;
neurogenic bladder;
silodosin
Keimyung Author(s)(Kor)
박철희
Publisher
School of Medicine
Citation
Kyung Hyun MOON et al. (2015). A 12-Week, Open Label, Multi-Center Study to Evaluate the Clinical Efficacy and Safety of Silodosin on Voiding Dysfunction in Patients with Neurogenic Bladder. Low Urin Tract Symptoms, 7(1), 27–31. doi: 10.1111/luts.12044
Type
Article
ISSN
1757-5664
Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/luts.12044
DOI
10.1111/luts.12044
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33409
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Urology (비뇨의학)
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