계명대학교 의학도서관 Repository

Manganese-enhanced auditory tract-tracing MRI with cochlear injection

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Author(s)
Jae-Won LeeJi-Ae ParkJae-Jun LeeSung-Jin BaeSang-Heun LeeJae-Chang JungMyoung-Nam KimJongmin LeeSeongku WooYongmin Chang
Keimyung Author(s)
Woo, Seong Ku
Department
Dept. of Radiology (영상의학)
Journal Title
Magnetic Resonance Imaging
Issued Date
2007
Volume
25
Issue
5
Keyword
Magnetic resonance imagingAuditoryManganeseContrast agent
Abstract
Recent studies have demonstrated the use of manganese ion (Mn2+) as an in vivo neuronal tract tracer. In contrast to histological approaches, manganese tracing can be performed repeatedly on the same living animal. In this study, we describe the neuroaxonal tracing of the auditory pathway in the living guinea pig, relying on the fact that Mn2+ ion enters excitable cells through voltage-gated calcium channels and is an excellent MRI paramagnetic tract-tracing agent. Small focal injections of Mn2+ ion into the cochlea produced significant contrast enhancement along the known neuronal circuitry. This in vivo approach, allowing repeated measures, is expected to open new vistas to study auditory physiology and to provide new insights on in vivo axonal transport and neuronal activity in the central auditory system.

Keywords
Auditory;
Magnetic resonance imaging;
Manganese;
Contrast agent
Keimyung Author(s)(Kor)
우성구
Publisher
School of Medicine
Citation
Jae-Won Lee et al. (2007). Manganese-enhanced auditory tract-tracing MRI with cochlear injection. Magnetic Resonance Imaging, 25(5), 652–656. doi: 10.1016/j.mri.2006.10.003
Type
Article
ISSN
0730-725X
Source
http://lps3.www.sciencedirect.com.proxy.dsmc.or.kr/science/article/pii/S0730725X06003110?via%3Dihub
DOI
10.1016/j.mri.2006.10.003
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33410
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Radiology (영상의학)
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