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Models for estimating the biological age of five organs using clinical biomarkers that are commonly measured in clinical practice settings

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Author(s)
Chul-Young BaeYoung Gon KangMei-Hua PiaoBeLong ChoKyung Hee ChoYong Kyu ParkByung Yeon YuSang-Wha LeeMoon Jong KimSang Hyun LeeYun-Jin KimDae-Hyun KimJong Sung KimJeong Eun Oh
Keimyung Author(s)
Kim, Dae Hyun
Department
Dept. of Family Medicine (가정의학)
Journal Title
Maturitas
Issued Date
2013
Volume
75
Issue
3
Keyword
Biological ageFive organsOrgan biomarkersAging biomarkers
Abstract
Objectives

To date, no worldwide studies have been conducted to estimate the biological age of five organs using clinical biomarkers that are associated with the aging status. Therefore, we conducted this study to develop the models for estimating the biological age of five organs (heart, lung, liver, pancreas, and kidney) using clinical biomarkers which are commonly measured in clinical practice.

Design

A cross sectional study.

Methods

Subjects were recruited from the routine health check-up centers in Korea from 2004 through 2010. Data obtained from 121,189 subjects (66,168 men and 55,021 women) were used for clinical evaluation and statistical analysis. We examined the relations between clinical biomarkers associated with five organs and the chronological age and proposed a model for estimating the biological age of five organs.

Results

In the models for predicting the biological ages of the heart, lung, liver, pancreas and kidney in men, 12, 2, 8, 3, and 5 parameters were respectively included (R2 = 0.652, 0.427, 0.107, 0.245, and 0.651). In contrast to men, 10, 2, 8, 3, and 5 parameters in women were respectively included (R2 = 0.780, 0.435, 0.140, 0.384, and 0.501).

Conclusion

We first proposed the models for predicting the biological age of five organs in the current study. We developed those using clinical parameters that can be easily obtained in clinical practice settings. Our biological age prediction models may be used as supplementary tools to assess the aging status of five organs in clinical practice settings.

Keywords
Biological age;
Five organs;
Organ biomarkers;
Aging biomarkers
Keimyung Author(s)(Kor)
김대현
Publisher
School of Medicine
Citation
Chul-Young Bae et al. (2013). Models for estimating the biological age of five organs using clinical biomarkers that are commonly measured in clinical practice settings. Maturitas, 75(3), 253–260. doi: 10.1016/j.maturitas.2013.04.008
Type
Article
ISSN
0378-5122
Source
http://lps3.www.sciencedirect.com.proxy.dsmc.or.kr/science/article/pii/S0378512213001199?via%3Dihub
DOI
10.1016/j.maturitas.2013.04.008
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33412
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Family Medicine (가정의학)
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