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Regulation of K+ channels may enhance wound healing in the skin

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Author(s)
Dawon KangTae Hyun ChoiKihwan HanDaegu SonJun Hyung KimSang-Hyon KimJungbin Park
Keimyung Author(s)
Choi, Tae HyunHan, Ki HwanSon, Dae GuKim, Jun HyungKim, Sang Hyon
Department
Dept. of Plastic Surgery (성형외과학)
Dept. of Internal Medicine (내과학)
Journal Title
Medical Hypotheses
Issued Date
2008
Volume
71
Issue
6
Abstract
In the process of promoting wound healing, epidermal growth factor (EGF) activates protein kinase C,
protein tyrosine kinase and ERK MAPK (mitogen-activated protein kinase). The activation of these mediators in signal
pathways can regulate the operation of K+ channels. In addition, the K+ channel is involved with cell migration and
proliferation, both of which are requisite for wound healing. Recent studies, although not conducted on skin wounds,
have found that the K+ channel is associated with wound healing and that wound healing can be promoted by regulating
the K+ channels. Therefore, the authors hypothesize that healing of skin wounds could be promoted by regulating K+
channel distribution in skin keratinocytes or fibroblasts. We plan to conduct a study of the promotion of skin wound
healing using K+ channel regulators.
Keimyung Author(s)(Kor)
최태현
한기환
손대구
김준형
김상현
Publisher
School of Medicine
Citation
Dawon Kang et al. (2008). Regulation of K+ channels may enhance wound healing in the skin. Medical Hypotheses, 71(6), 927–929. doi: 10.1016/j.mehy.2008.05.038
Type
Article
ISSN
0306-9877
Source
http://lps3.www.sciencedirect.com.proxy.dsmc.or.kr/science/article/pii/S0306987708003459?via%3Dihub
DOI
10.1016/j.mehy.2008.05.038
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33415
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Plastic Surgery (성형외과학)
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