Regulation of K+ channels may enhance wound healing in the skin
- Author(s)
- Dawon Kang; Tae Hyun Choi; Kihwan Han; Daegu Son; Jun Hyung Kim; Sang-Hyon Kim; Jungbin Park
- Keimyung Author(s)
- Choi, Tae Hyun; Han, Ki Hwan; Son, Dae Gu; Kim, Jun Hyung; Kim, Sang Hyon
- Department
- Dept. of Plastic Surgery (성형외과학)
Dept. of Internal Medicine (내과학)
- Journal Title
- Medical Hypotheses
- Issued Date
- 2008
- Volume
- 71
- Issue
- 6
- Abstract
- In the process of promoting wound healing, epidermal growth factor (EGF) activates protein kinase C,
protein tyrosine kinase and ERK MAPK (mitogen-activated protein kinase). The activation of these mediators in signal
pathways can regulate the operation of K+ channels. In addition, the K+ channel is involved with cell migration and
proliferation, both of which are requisite for wound healing. Recent studies, although not conducted on skin wounds,
have found that the K+ channel is associated with wound healing and that wound healing can be promoted by regulating
the K+ channels. Therefore, the authors hypothesize that healing of skin wounds could be promoted by regulating K+
channel distribution in skin keratinocytes or fibroblasts. We plan to conduct a study of the promotion of skin wound
healing using K+ channel regulators.
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