계명대학교 의학도서관 Repository

Clinical Experience of Tigecycline Treatment in Infections Caused by Extensively Drug-Resistant Acinetobacter spp.

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Author(s)
Soo-Youn MoonKyong Ran PeckHyun-Ha ChangShin-Woo KimSang Taek HeoJun Seong SonSeong Yeol RyuChisook MoonSook-In JungSang Yop ShinJeong-a LeeMi-Kyong JoungDoo-Ryeon ChungCheol-In KangJae-Hoon Song
Keimyung Author(s)
Ryu, Seong Yeol
Department
Dept. of Internal Medicine (내과학)
Journal Title
Microbial Drug Resistance
Issued Date
2012
Volume
18
Issue
6
Abstract
Background: Tigecycline has broad spectrum antimicrobial activity and is approved for complicated intra-abdominal infections, complicated skin and soft tissue infections, and community-acquired pneumonia. There are few data on clinical experience of tigecycline in hospital-acquired pneumonia (HAP) and Acinetobacter spp. infection. Methods: A retrospective study was performed at eight hospitals in Korea from May 2009 to January 2010. Adult patients treated with tigecycline regardless of their source of infection or pathogens were enrolled. Results: Tigecycline was administered in 108 patients. Pneumonia was the most common infection (43.5%), followed by skin and soft tissue infections (20.4%). Acinetobacter baumannii was isolated from 83 patients (76.9%) accounting for 50.3% of isolated pathogens, showing a resistance rate of 67.5% to carbapenems. Superinfection was identified in 32 patients (29.6%). Pseudomonas aeruginosa was most common microorganism causing superinfection (46.9%). Overall 30-day mortality rate was 52.9%. Thirty-day mortality rate of HAP and Acinetobacter spp. infection was 60.5% and 59.4%, respectively. Conclusion: Tigecycline can be considered as an alternative therapy in patients with HAP or infections caused by Acinetobacter spp., especially extensively drug-resistant A. baumannii.
Keimyung Author(s)(Kor)
류성열
Publisher
School of Medicine
Citation
Soo-Youn Moon et al. (2012). Clinical Experience of Tigecycline Treatment in Infections Caused by Extensively Drug-Resistant Acinetobacter spp. Microbial Drug Resistance, 18(6), 562–566.
Type
Article
ISSN
1076-6294
Source
https://www.liebertpub.com/doi/abs/10.1089/mdr.2012.0010?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33424
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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