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Fecal Colonization of Enterobacteriaceae Carrying Plasmid-Mediated Quinolone Resistance Determinants in Korea

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Author(s)
Haeng Soon JeongIl Kwon BaeJeong Hwan ShinSi Hyun KimChulhun L. ChangJoseph JeongSunjoo KimChae Hoon LeeNam Hee RyooJeong Nyeo Lee
Keimyung Author(s)
Ryoo, Nam Hee
Department
Dept. of Laboratory Medicine (진단검사의학)
Journal Title
Microbial Drug Resistance
Issued Date
2011
Volume
17
Issue
4
Abstract
The aims of the current study were to investigate the prevalence and molecular characteristics of plasmidmediated
quinolone resistance (PMQR) genes from colonizing fecal organisms and to compare the incidence and
subtype of these genes according to bacterial species and hospital at five tertiary-care hospitals in Korea. A total
of 500 nonduplicated clinical isolates of Enterobacteriaceae were obtained from fecal specimens at five tertiary-care
hospitals between March and May 2008. The PMQR genes (qnrA, qnrB, qnrS, aac(6’)-Ib-cr, and qepA) were
amplified by PCR and confirmed by direct sequencing of the PCR products. A total of 83 (16.6%) qnr-positive
isolates were detected. The prevalence rates of qnrA, qnrB, and qnrS were 1.4%, 13.6%, and 1.6%, respectively.
The species distributions of qnrB-positive isolates were Klebsiella pneumoniae (37/109; 33.9%), Citrobacter freundii
(10/34; 29.4%), Citrobacter braakii (8/13; 61.5%), and Escherichia coli (8/275; 2.9%). Sixteen subtypes of qnrB were
detected, including seven novel variants. The prevalences of aac(6’)-Ib-cr and qepA were 15.6% (n = 78) and 0.6%
(n = 3), respectively. The aac(6’)-Ib-cr gene was detected in 39 (47.0%) of 83 qnr-positive isolates and 39 (9.4%) of
417 qnr-negative isolates There was one qepA variant containing a novel mutation (Ala231Val). The prevalence of
PMQR genes was high in Enterobacteriaceae from stool specimens in Korea, and there was a close relation
between qnr and aac(6’)-Ib-cr.
Keimyung Author(s)(Kor)
류남희
Publisher
School of Medicine
Citation
Haeng Soon Jeong et al. (2011). Fecal Colonization of Enterobacteriaceae Carrying Plasmid-Mediated Quinolone Resistance Determinants in Korea. Microbial Drug Resistance, 17(4), 507–512.
Type
Article
ISSN
1076-6294
Source
https://www.liebertpub.com/doi/abs/10.1089/mdr.2011.0040?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33425
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학)
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