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Fluoroquinolone Resistance in Uncomplicated Acute Pyelonephritis : Epidemiology and Clinical Impact

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Author(s)
Hee Jin CheongSun Hee ParkDae Won ParkSeong Yeol RyuMoon-Hyun ChungSunmi YooHyunjoo PaiJaehyun ShinJieun KimSeong-Heon WieYoung Kyun ChoSeung-Kwan LimSang Yop ShinJoon-Sup YeomJin Seo LeeKi Tae KwonHyuck Lee
Keimyung Author(s)
Ryu, Seong Yeol
Department
Dept. of Internal Medicine (내과학)
Journal Title
Microbial Drug Resistance
Issued Date
2012
Volume
18
Issue
2
Abstract
The objectives of this study were to investigate antibiotic resistance in urinary pathogens from Korean patients
with uncomplicated acute pyelonephritis (UAPN), and to determine the effect of fluoroquinolone (FQ) resistance
on clinical outcome in those patients with UAPN initially treated with FQ. Clinical and microbiologic data for
all the APN patients attending 14 hospitals in South Korea in 2008 were collected retrospectively. Urinary
pathogens were identified in 719 cases, and Escherichia coli was the most common pathogen (661/719, 91.9%).
Antibiotic susceptibilities to several E. coli antibiotics were as follows: ciprofloxacin, 84.1%; trimethoprimsulfamethoxazola
(TMP-SMX), 67.2%; and extended-spectrum beta-lactamase-negative, 92.4%. FQ was the most
frequent antibiotic prescribed for UAPN (45.3% intravenously and 53.9% by mouth). We compared clinical
outcomes and hospital days in patients with FQ-resistant (32) and FQ-sensitive E. coli (173) who received FQ as
initial empirical therapy. Clinical cure was higher in the FQ-sensitive group (78% vs. 91%, p = 0.027), and hospital
days were longer in the FQ-resistant group (9.6 – 5.5 days vs. 7 – 3.5 days, p = 0.001). In conclusion, FQ-sensitivity
of E. coli from UAPN was 84.1%. FQ treatment of UAPN caused by FQ-resistant E. coli has a lower cure rate and
involves longer hospital stay than FQ treatment of cases caused by FQ-sensitive E. coli.
Keimyung Author(s)(Kor)
류성열
Publisher
School of Medicine
Citation
Hee Jin Cheong et al. (2012). Fluoroquinolone Resistance in Uncomplicated Acute Pyelonephritis : Epidemiology and Clinical Impact. Microbial Drug Resistance, 18(2), 169–175.
Type
Article
ISSN
1076-6294
Source
https://www.liebertpub.com/doi/abs/10.1089/mdr.2011.0139?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33426
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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