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Regulation of singlet oxygen-induced apoptosis by cytosolic NADP+-dependent isocitrate dehydrogenase

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Author(s)
Sun Yee KimSu Min LeeJean Kyoung TakKyeong Sook ChoiTaeg Kyu KwonJeen-Woo Park
Keimyung Author(s)
Kwon, Taeg Kyu
Department
Dept. of Immunology (면역학)
Journal Title
Molecular and Cellular Biochemistry
Issued Date
2007
Volume
302
Issue
1
Keyword
Singlet oxygenIsocitrate dehydrogenaseHL-60ApoptosisAntioxidant enzyme
Abstract
Singlet oxygen is a highly reactive form of molecular oxygen that may harm living systems by oxidizing critical cellular macromolecules and it also promotes deleterious processes such as cell death. Recently, we demonstrated that the control of redox balance and the cellular defense against oxidative damage are the primary functions of cytosolic NADP+-dependent isocitrate dehydrogenase (IDPc) through supplying NADPH for antioxidant systems. In this report, we demonstrate that modulation of IDPc activity in HL-60 cells regulates singlet oxygen-induced apoptosis. When we examined the protective role of IDPc against singlet oxygen-induced apoptosis with HL-60 cells transfected with the cDNA for mouse IDPc in sense and antisense orientations, a clear inverse relationship was observed between the amount of IDPc expressed in target cells and their susceptibility to apoptosis. The results suggest that IDPc plays an important protective role in apoptosis of HL-60 cells induced by singlet oxygen.

Keywords: Singlet oxygen; Isocitrate dehydrogenase; HL-60; Apoptosis; Antioxidant enzyme
Keimyung Author(s)(Kor)
권택규
Publisher
School of Medicine
Citation
Sun Yee Kim et al. (2007). Regulation of singlet oxygen-induced apoptosis by cytosolic NADP+-dependent isocitrate dehydrogenase. Molecular and Cellular Biochemistry, 302(1), 27–34. doi: 10.1007/s11010-007-9421-x
Type
Article
ISSN
0300-8177
Source
http://lps3.link.springer.com.proxy.dsmc.or.kr/article/10.1007%2Fs11010-007-9421-x
DOI
10.1007/s11010-007-9421-x
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33440
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
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