계명대학교 의학도서관 Repository

Transmodulation between phospholipase D and c-Src enhances cell proliferation

Metadata Downloads
Author(s)
Bong-Hyun AhnShi Yeon KimEun Hee KimKyeong Sook ChoiTaeg Kyu KwonYoung Han LeeJong-Soo ChangMyung-Suk KimYang-Hyeok JoDo Sik Min
Keimyung Author(s)
Kwon, Taeg Kyu
Department
Dept. of Immunology (면역학)
Journal Title
Molecular and Celluar Biology
Issued Date
2003
Volume
23
Issue
9
Abstract
Phospholipase D (PLD) has been implicated in the signal transduction pathways initiated by several mitogenic protein tyrosine kinases. We demonstrate for the first time that most notably PLD2 and to a lesser extent the PLD1 isoform are tyrosine phosphorylated by c-Src tyrosine kinase via direct association. Moreover, epidermal growth factor induced tyrosine phosphorylation of PLD2 and its interaction with c-Src in A431 cells. Interaction between these proteins is via the pleckstrin homology domain of PLD2 and the catalytic domain of c-Src. Coexpression of PLD1 or PLD2 with c-Src synergistically enhances cellular proliferation compared with expression of either molecule. While PLD activity as a lipid-hydrolyzing enzyme is not affected by c-Src, wild-type PLDs but not catalytically inactive PLD mutants significantly increase c-Src kinase activity, up-regulating c-Src-mediated paxillin phosphorylation and extracellular signal-regulated kinase activity. These results demonstrate the critical role of PLD catalytic activity in the stimulation of Src signaling. In conclusion, we provide the first evidence that c-Src acts as a kinase of PLD and PLD acts as an activator of c-Src. This transmodulation between c-Src and PLD may contribute to the promotion of cellular proliferation via amplification of mitogenic signaling pathways.
Keimyung Author(s)(Kor)
권택규
Publisher
School of Medicine
Citation
Bong-Hyun Ahn et al. (2003). Transmodulation between phospholipase D and c-Src enhances cell proliferation. Molecular and Celluar Biology, 23(9), 3103–3115. doi: 10.1128/MCB.23.9.3103-3115.2003
Type
Article
ISSN
0270-7306
DOI
10.1128/MCB.23.9.3103-3115.2003
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33442
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.