계명대학교 의학도서관 Repository

The Expression and Characterization of Cyclin-dependent Kinase 6 during the Activation of Murine G0 T-Cells

Metadata Downloads
Author(s)
Taeg Kyu KwonJong-Wook ParkMeredith A. BuchholzAlbert A. Nordin
Keimyung Author(s)
Kwon, Taeg KyuPark, Jong Wook
Department
Dept. of Immunology (면역학)
Journal Title
Molecules and Cells
Issued Date
2001
Volume
12
Issue
3
Keyword
Cdk6Cell CycleD-Type CyclinT Lymphocytes
Abstract
Recent evidence strongly suggest that the D type cy-clins with cdk4 and cdk6 form holoenzymes that regu-late cell cycle events earlier in G1 than cyclin E/cdk2 complexes which functions near the G1/S transition. In human T lymphocytes cdk6 has been shown to be the initial retinoblastoma protein kinase detectable at mid G1. Following activation of splenic derived murine G0T-cells, cdk6, cyclin D2 and D3 specific mRNAs were detected early in G1 and reached maximal levels prior to or near G1/S. The phosphorylation of retino-blastoma protein from T-cells was detected very early in G1 and was associated mainly with cdk6/cyclin D2 complexes which accounted for a minor portion of the total cellular cdk6 contained in the cytoplasmic frac-tion of T-cells and mostly in the catalytically inactive form.Keywords: D-Type Cyclin, Cdk6, Cell Cycle, T Lymphocytes
Keimyung Author(s)(Kor)
권택규
박종욱
Publisher
School of Medicine
Citation
Taeg Kyu Kwon et al. (2001). The Expression and Characterization of Cyclin-dependent Kinase 6 during the Activation of Murine G0 T-Cells. Molecules and Cells, 12(3), 313–320.
Type
Article
ISSN
1016-8478
Source
http://www.molcells.org/journal/view.html?year=2001&volume=12&number=3&spage=313
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33443
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.