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Growth inhibition and apoptosis induced in human leiomyoma cells by treatment with the PPAR gamma ligand ciglitizone

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Author(s)
Dong-Ho NamSabarish RamachandranDae-Kyu SongKun-Young KwonDong-Seok JeonSo-Jin ShinSang-Hoon KwonSoon-Do ChaInsoo BaeChi-Heum Cho
Keimyung Author(s)
Shin, So JinKwon, Sang HoonCha, Soon DoCho, Chi HeumSong, Dae KyuKwon, Kun YoungJeon, Dong Seok
Department
Dept. of Obstetrics & Gynecology (산부인과학)
Dept. of Physiology (생리학)
Dept. of Pathology (병리학)
Dept. of Laboratory Medicine (진단검사의학)
Journal Title
Molecular Human Reproduction
Issued Date
2007
Volume
13
Issue
11
Keyword
uterine leiomyomaPPARγciglitizoneapoptosis
Abstract
The nuclear receptors PPARs (peroxisome proliferator-activated receptors) are transcription factors that play important roles in multiple disease conditions. The activation of PPARs by specific ligands is associated with growth suppression of several different types of human cancer, but the molecular mechanism responsible for this growth suppressive effect remains elusive. The aim of this study was to determine the distribution of PPARγ protein/mRNA expression in uterine leiomyomas and to identify the PPARγ induced signaling pathways responsible for the growth inhibition induced by treatment with ciglitizone, a synthetic ligand of PPARγ, in view of identifying targets that could possibly affect the viability and proliferation of uterine leiomyoma cells. Dose–response studies on proliferation found that uterine leiomyoma was more sensitive to inhibition by ciglitizone treatments than normal myometrium. We also found that ciglitizone significantly stimulated gene expression driven by a PPAR-responsive element in cultured leiomyoma cells and reduced the survival of leiomyoma cells relative to the control cells. The reduced survival of ciglitizone treated leiomyoma cells resulted from a mechanism that involved the Fas receptor-mediated apoptosis signaling cascade. These results suggest that uterine leiomyomas growth and differentiation might be modulated through PPARγ receptors and that PPARγ ligands may be of potential use for uterine leiomyoma treatment.
Key words: uterine leiomyoma; PPARγ; ciglitizone; apoptosis
Keimyung Author(s)(Kor)
신소진
권상훈
차순도
조치흠
송대규
권건영
전동석
Publisher
School of Medicine
Citation
Dong-Ho Nam et al. (2007). Growth inhibition and apoptosis induced in human leiomyoma cells by treatment with the PPAR gamma ligand ciglitizone. Molecular Human Reproduction, 13(11), 829–836. doi: 10.1093/molehr/gam071
Type
Article
ISSN
1360-9947
Source
https://academic.oup.com/molehr/article-lookup/doi/10.1093/molehr/gam071
DOI
10.1093/molehr/gam071
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33445
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학)
1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Physiology (생리학)
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