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Protection from Bacterial-Toxin-Induced Apoptosis in Macrophages Requires the Lipogenic Transcription Factor Sterol Regulatory Element Binding Protein 1a

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Author(s)
Seung-Soon ImTimothy F. Osborne
Keimyung Author(s)
Im, Seung Soon
Department
Dept. of Physiology (생리학)
Journal Title
Molecular and Cellular Biology
Issued Date
2012
Volume
32
Issue
12
Abstract
Sterol regulatory element binding protein (SREBP) transcription factors activate genes of lipid metabolism, but recent studies indicate they also activate genes involved in other physiologic processes, suggesting that SREPBs have evolved to connect lipid metabolism with diverse physiologic responses. There are three major mammalian SREBPs, and the 1a isoform is specifically expressed at very high levels in macrophages, where a recent study showed that it couples lipid synthesis to the proinflammatory phase of the innate immune response. In the present study, we show that loss of SREBP-1a also results in an increase in apoptosis after exposure to bacterial pore-forming toxins and we show this is a result of a selective reduction in the expression of the gene coding for the antiapoptotic factor apoptosis inhibitor 6 (Api6). Additional studies demonstrate that SREBP-1a specifically activates the Api6 gene through a binding site in its proximal promoter, thus establishing the Api6 gene as a newly identified SREBP-1a target gene.
Keimyung Author(s)(Kor)
임승순
Publisher
School of Medicine
Citation
Seung-Soon Im and Timothy F. Osborne. (2012). Protection from Bacterial-Toxin-Induced Apoptosis in Macrophages Requires the Lipogenic Transcription Factor Sterol Regulatory Element Binding Protein 1a. Molecular and Cellular Biology, 32(12), 2196–2202. doi: 10.1128/MCB.06294-11
Type
Article
ISSN
0270-7306
DOI
10.1128/MCB.06294-11
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33448
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Physiology (생리학)
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