계명대학교 의학도서관 Repository

Cellular glucose availability and glucagon-like peptide-1

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Author(s)
Jae-Hyung ParkYung E. EarmDae-Kyu Song
Keimyung Author(s)
Park, Jae HyungSong, Dae Kyu
Department
Dept. of Physiology (생리학)
Journal Title
Progress in Biophysics and Molecular Biology
Issued Date
2011
Volume
107
Issue
2
Keyword
Glucagon-like peptide-1Type 2 diabetesGlucose uptakePancreatic b-cellGlucokinaseInsulin secretion
Abstract
Glucagon-like peptide (GLP)-1 and gastric inhibitory polypeptide (GIP, glucose-dependent insulinotropic polypeptide) are produced in enteroendocrine L-cells and K-cells, respectively. They are known as incretins because they potentiate postprandial insulin secretion. Although unresponsiveness of type 2 diabetes (T2D) patients to GIP has now been reconsidered, GLP-1 mimetics and inhibitors of the GLP-1 degradation enzyme dipeptidyl peptidase (DPP)-4 have now been launched as drugs against T2D. The major roles of GLP-1 in T2D are reduction of appetite, gastric motility, glucagon secretion, enhancement of insulin secretion and β-cell survival. For insulin secretion and peripheral insulin function, GLP-1 and its mimetics sensitise β-cells to glucose; accelerate blood glucose withdrawal, in-cell glucose utilisation and glycogen synthesis in insulin-sensitive tissues; and assist in the function and survival of neurons mainly using glucose as an energy source. Taken together, GLP-1 acts to potentiate glucose availability of various cells or tissues to assist with their essential functions and/or survival. Herein, we review the signalling pathways and clinical relevance of GLP-1 in enhancing cellular glucose availability. On the basis of our recent research results, we also describe a mechanism that regulates GLP-1 for glucokinase activity. Because diabetic tissues including β-cells resist glucose, GLP-1 may be useful for treating T2D.

Keywords
Glucagon-like peptide-1;
Type 2 diabetes;
Glucose uptake;
Pancreatic β-cell;
Glucokinase;
Insulin secretion
Keimyung Author(s)(Kor)
박재형
송대규
Publisher
School of Medicine
Citation
Jae-Hyung Park et al. (2011). Cellular glucose availability and glucagon-like peptide-1. Progress in Biophysics and Molecular Biology, 107(2), 286–292. doi: 10.1016/j.pbiomolbio.2011.08.009
Type
Article
ISSN
0079-6107
Source
https://www.sciencedirect.com/science/article/pii/S0079610711000940?via%3Dihub
DOI
10.1016/j.pbiomolbio.2011.08.009
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33453
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Physiology (생리학)
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