계명대학교 의학도서관 Repository

Proteomic and cytokine plasma biomarkers for predicting progression from colorectal adenoma to carcinoma in human patients

Metadata Downloads
Author(s)
Jung-Won ChoiHao LiuDong Hoon ShinGyeong Im YuJae Seok HwangEun Soo KimJong Won Yun
Keimyung Author(s)
Shin, Dong HoonHwang, Jae SeokKim, Eun Soo
Department
Dept. of Preventive Medicine (예방의학)
Dept. of Internal Medicine (내과학)
Journal Title
Proteomics
Issued Date
2013
Volume
13
Issue
15
Keyword
2DEAdenomaBiomarkerBiomedicineCarcinomaPlasma proteome
Abstract
In the present study, we screened proteomic and cytokine biomarkers between patients with adenomatous polyps and colorectal cancer (CRC) in order to improve our understanding of the molecular mechanisms behind turmorigenesis and tumor progression in CRC. To this end, we performed comparative proteomic analysis of plasma proteins using a combination of 2DE and MS as well as profiled differentially regulated cytokines and chemokines by multiplex bead analysis. Proteomic analysis identified 11 upregulated and 13 downregulated plasma proteins showing significantly different regulation patterns with diagnostic potential for predicting progression from adenoma to carcinoma. Some of these proteins have not previously been implicated in CRC, including upregulated leucine-rich α-2-glycoprotein, hemoglobin subunit β, Ig α-2 chain C region, and complement factor B as well as downregulated afamin, zinc-α-2-glycoprotein, vitronectin, and α-1-antichymotrypsin. In addition, plasma levels of three cytokines/chemokines, including interleukin-8, interferon gamma-induced protein 10, and tumor necrosis factor α, were remarkably elevated in patients with CRC compared to those with adenomatous polyps. Although further clinical validation is required, these proteins and cytokines can be established as novel biomarkers for CRC and/or its progression from colon adenoma.

© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


KEYWORDS:

2DE; Adenoma; Biomarker; Biomedicine; Carcinoma; Plasma proteome
Keimyung Author(s)(Kor)
신동훈
황재석
김은수
Publisher
School of Medicine
Citation
Jung-Won Choi et al. (2013). Proteomic and cytokine plasma biomarkers for predicting progression from colorectal adenoma to carcinoma in human patients. Proteomics, 13(15), 2361–2374. doi: 10.1002/pmic.201200550
Type
Article
ISSN
1615-9853
Source
http://lps3.onlinelibrary.wiley.com.proxy.dsmc.or.kr/doi/abs/10.1002/pmic.201200550
DOI
10.1002/pmic.201200550
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33456
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.